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    Family stable cell lines 5-Hydroxytryptamine Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human HTR4 Stable Cell Line

    [CAT#: S01YF-0923-KX38]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX928 Magic™ Rat HTR4 in Vitro cAMP Assay Rat CHO-K1 cAMP Assay

    Product Information

    Target Protein
    HTR4
    Target Family
    5-Hydroxytryptamine Family
    Target Protein Species
    Human
    Host Cell Type
    COS7; CHO-K1; HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research; Digestive and Renal Research
    Related Diseases
    Irritable Bowel Syndrome; Constipation
    Gene ID
    3360
    UniProt ID
    Q13639

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    HTR4 receptors regulate the release of numerous neurotransmitters, including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, and cortisol. They also govern both excitatory and inhibitory neurotransmission. By regulating the release of different neurotransmitters, HTR4 affects both peripheral and central nervous system processes such as the sleep-wake cycle, thermoregulation, food intake, nociception, locomotion, sexual behavior, gastrointestinal motility, blood coagulation, and cardiovascular homeostasis. G proteins that stimulate adenylate cyclase and aid in the production of cAMP mediate the activity of HTR4. HTR4 is thought to intensify inflammatory pain and has been linked to inflammatory hyperalgesia. In mouse models of depression, studies have demonstrated that an HTR4 agonist partially exhibits antidepressant-like effects. The customized HTR4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

    Protocols

    Please visit our protocols page.

    Customer Reviews

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    FAQ

    chat Channing (Verified Customer)

    Can the HTR4 cell line be used in PPI studies? Feb 19 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Yes, cell lines expressing specific proteins can be used in PPI studies. Feb 19 2023

    chat Sigrid (Verified Customer)

    Does the HTR4 stable cell line overexpress the full-length HTR4? Sep 02 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Yes, the HTR4 stable cell line can be customized to overexpress the full-length HTR4. Sep 02 2023

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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