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    mProX™ Human HTR3A Stable Cell Line

    [CAT#: S01YF-0923-KX37]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    HTR3A
    Target Family
    5-Hydroxytryptamine Family
    Target Protein Species
    Human
    Host Cell Type
    DLD-1; HCT116; SW1116; SW620; CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    CNS Research; Reproductive Research
    Related Diseases
    Serotonin Syndrome; Motion Sickness
    Gene ID
    3359
    UniProt ID
    P46098

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Serotonin, also known as 5-hydroxytryptamine (5-HT), was first discovered in the blood as a vasoconstrictor. The ligand-gated cation channel subunit may be encoded by the 5-HT3 subtype, which contains three subunits: 5-HT3A (also known as HTR3A), 5-HT3B (also known as HTR3B), and HTR3C. As a homo-pentamer, the HTR3A subunit creates a functional channel. In the six CRC cell lines, HTR3A expression varied. Additionally, HTR3A knockdown prevented CRC cells from proliferating and forming colonies, which induced cell cycle arrest and encouraged cell death. Additionally, following HTR3A knockdown, the expression of apoptosis-related proteins like BAD and BAX was elevated whereas Bcl2 expression was lowered. The customized HTR3A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human HTR3A Stable Cell Line (S01YF-0923-KX37). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Philip (Verified Customer)

    What host cells are typically used for the HTR3A stable cell line? Aug 18 2022

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Mammalian cells such as HEK293 or CHO-K1. Aug 18 2022

    chat Burgess (Verified Customer)

    Is it possible to infer information about the important cell type from the STR profile? Nov 05 2022

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Yes, but to distinguish between different cell populations or cell types, cell clusters must first be manually annotated using flag genes unique to the animal or tissue under study. Nov 05 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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