mProX™ Human HTR2C Stable Cell Line

Product Information

Target Protein

HTR2C

Target Family

5-Hydroxytryptamine Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research; Reproductive Research

Related Diseases

Premature Ejaculation; Anxiety

Gene ID

3358

UniProt ID

P28335

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

One of the numerous binding sites for serotonin is the HTR2C receptor. The brain's short-term receptor potential calcium channels, which are activated by HTR2C, may control neuronal activity. This, in turn, controls the activation of proopiomelanocortin neurons and the release of CRH, which in turn controls the release of corticosterone. HTR2C is thought to have a crucial role in controlling mood, anxiety, feeding, and sexual behavior. In some parts of the brain, activation of HTR2C may prevent the release of dopamine and norepinephrine. HTR2C also contributes to glucose homeostasis and insulin sensitivity. Several research have suggested that the prefrontal cortex of certain suicide victims contains an abnormally high number of HTR2C receptors. The customized HTR2C stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Queena (Verified Customer)

What are the mycoplasma analysis methods? Dec 15 2022

chat Sherry Smith (Creative Biolabs Scientific Support)

Mycoplasma testing is performed using a Mycoplasma Detection Kit. Dec 15 2022

chat Vanessa (Verified Customer)

What's applications of this cell line? May 07 2023

chat Sherry Smith (Creative Biolabs Scientific Support)

The HTR2C stable cell line can be used in various research applications, like antibody discovery and development, potential drug candidate screening and signaling pathway researches. May 07 2023

Published Data

Fig.1 Htr2c cells are activated in attention.

After breeding CaMPARIloxP/loxP mice with Htr2c-Cre mice, low- and high-magnification images demonstrate CaMPARI expression in Htr2c cells.

Ref: Li, Xinyan, et al. "Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus." Nature neuroscience 21.9 (2018): 1239-1250.

Pubmed: 30104733

DOI: 10.1038/s41593-018-0207-0

Research Highlights

This study provides evidence that the amount of food consumed and the nutritional status of children may be influenced by genetic variations of these proteins.
Miranda, Raquel CK, et al. "SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children." Clinical biochemistry 48.18 (2015): 1277-1282.
Pubmed: 26160208 DOI: 10.1016/j.clinbiochem.2015.07.003

The significance of Htr2c pre-mRNA processing to the physiological regulation of hunger and perhaps the pathological presentation of hyperphagia in PWS is revealed by our studies, which offer novel information.
Garfield, Alastair S., et al. "Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT 2C receptor mediated appetite." Molecular brain 9 (2016): 1-9.
Pubmed: 27931246 DOI: 10.1186/s13041-016-0277-4