mProX™ Human HTR2B Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Expression of HTR2B in response to stimulation with IL-4 and IL-6.
In both T142 and T143 UM cells grown either alone (Ctl) or in the presence of escalating amounts of IL4 and IL6 (100 pM to 1 M), the expression of HTR2B was examined by Western blot. Values for the ratio of the HTR2B signal to the actin signal are displayed beneath each blot. Comparing treated (positive controls) and untreated (negative controls) T142 and T143 UM cells, both IL-4 and IL-6 markedly elevated expression of HTR2B.
Ref: Benhassine, Manel, Gaëtan Le-Bel, and Sylvain L. Guérin. "Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma." International Journal of Molecular Sciences 23.3 (2022): 1564.
Pubmed: 35163491
DOI: 10.3390/ijms23031564
Research Highlights
Increased 5-HT signaling via HTR2B directly induced lipolysis in visceral adipocytes by phosphorylating hormone-sensitive lipase. Furthermore, administration of a specific HTR2B antagonist reduced the inflammation, steatosis, and insulin resistance of the HFD-induced visceral adipose tissue. As a result, adipose HTR2B signaling may provide a promising therapeutic target for the management of insulin resistance brought on by obesity.
Choi, Won Gun, et al. "Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity-related insulin resistance." The Journal of Clinical Investigation 131.23 (2021).
Pubmed:
34618686
DOI:
10.1172/JCI145331
A function for 5-HT2B receptors in the neurobiology of psychotic diseases is first demonstrated by the extensive range of antipsychotic-sensitive schizophrenic-like behavioral and psychopharmacological characteristics that are conferred by 5-HT2B receptor loss in mice.
Pitychoutis, Pothitos M., et al. "Mice lacking the serotonin Htr2B receptor gene present an antipsychotic-sensitive schizophrenic-like phenotype." Neuropsychopharmacology 40.12 (2015): 2764-2773.
Pubmed:
25936642
DOI:
10.1038/npp.2015.126
