mProX™ Human HTR1B Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Sherry Smith (Creative Biolabs Scientific Support)
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Published Data
Fig.1 HTR1B dowregulation impairs survival and clongenicity of AML cells.
Representative flow cytometry histograms of HTR1B surface expression on AML cell lines and normalized HTR1B expression levels (mean fluorescence intensity (MFI)) of transduced AML cell lines. It is evident that HTR1B surface expression has decreased.
Ref: Etxabe, A., et al. "Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target." Leukemia 31.11 (2017): 2288-2302.
Pubmed: 28193998
DOI: 10.1038/leu.2017.52
Research Highlights
These observations, which were acquired from two separate samples, offer fresh light on the neurological underpinnings of psychopathy and have positive therapeutic and forensic ramifications.
Palumbo, Sara, et al. "HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment." Psychoneuroendocrinology 144 (2022): 105861.
Pubmed:
35853382
DOI:
10.1016/j.psyneuen.2022.105861
These findings provide additional support for the possibility that genetic and epigenetic variables influence HTR1B expression and the pharmacological response to antidepressants.
Gassó, Patricia, et al. "Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine." Progress in Neuro-Psychopharmacology and Biological Psychiatry 75 (2017): 28-34.
Pubmed:
28025020
DOI:
10.1016/j.pnpbp.2016.12.003
