mProX™ Human HTR1B Stable Cell Line

[CAT#: S01YF-0923-KX31]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types
S01YF-1122-KX880	Magic™ Human HTR1B in Vitro [35S]GTPγS binding Assay	Human	CHO-K1	[35S]GTPγS binding Assay
S01YF-1122-KX881	Magic™ Human HTR1B in Vitro Radioligand Binding Assay	Human	CHO-K1	Radioligand Binding Assay
S01YF-1122-KX877	Magic™ Dog HTR1B in Vitro [35S]GTPγS binding Assay	Dog	CHO-K1	[35S]GTPγS binding Assay
S01YF-1122-KX878	Magic™ Dog HTR1B in Vitro Radioligand Binding Assay	Dog	CHO-K1	Radioligand Binding Assay
S01YF-1122-KX882	Magic™ Mouse HTR1B in Vitro [35S]GTPγS binding Assay	Mouse	CHO-K1	[35S]GTPγS binding Assay
S01YF-1122-KX883	Magic™ Mouse HTR1B in Vitro Radioligand Binding Assay	Mouse	CHO-K1	Radioligand Binding Assay
S01YF-1122-KX884	Magic™ Rabbit HTR1B in Vitro Radioligand Binding Assay	Rabbit	CHO-K1	Radioligand Binding Assay
S01YF-1122-KX885	Magic™ Rat HTR1B in Vitro cAMP Assay	Rat	CHO-K1	cAMP Assay
S01YF-1122-KX886	Magic™ Rat HTR1B in Vitro [35S]GTPγS binding Assay	Rat	CHO-K1	[35S]GTPγS binding Assay
S01YF-1122-KX887	Magic™ Rat HTR1B in Vitro Radioligand Binding Assay	Rat	CHO-K1	Radioligand Binding Assay

Product Information

Target Protein

HTR1B

Target Family

5-Hydroxytryptamine Family

Target Protein Species

Human

Host Cell Type

AML; CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research

Related Diseases

Obsessive-Compulsive Disorder; Personality Disorder

Gene ID

3351

UniProt ID

P28222

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

At least 14 different classes of serotonin receptor subtypes are involved in the neuromodulatory effects of serotonin on brain function. An inhibitory neurotransmission is mediated by the G-protein coupled receptor HTR1B, which also controls the release of serotonin, dopamine, and acetylcholine in the brain. Attention deficit hyperactivity disorder (ADHD), antisocial conduct, aggressive behavior, bipolar illness, anxiety/depression, schizophrenia, and substance misuse have all been linked to HTR1B, according to some research. It is also a frequent target for medicines used for therapy. The customized HTR1B stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Paddy (Verified Customer)

How is the stability of the HTR1B protein ensured in the stable cell line? Jun 28 2023

chat Sherry Smith (Creative Biolabs Scientific Support)

The stability of the HTR1B protein is ensured through the use of specific cell culture conditions and the selection of cells that stably express the HTR1B protein. Jun 28 2023

chat Sebastiane (Verified Customer)

How do I select the right host cell? Mar 18 2023

chat Sherry Smith (Creative Biolabs Scientific Support)

You'll need to take into account your research objectives. A more physiologically appropriate cell type may be the ideal choice to achieve more pertinent results if you are examining cellular metabolism or the effects of particular nutrients on cellular activities. Mar 18 2023

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