mProX™ Human HRH3 Stable Cell Line

[CAT#: S01YF-0923-PY89]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

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Lot Number

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types
S01YF-1122-KX531	Magic™ Dog HRH3 in Vitro [35S]GTPγS binding Assay	Dog	CHO-K1	[35S]GTPγS binding Assay
S01YF-1122-KX536	Magic™ Rat HRH3 in Vitro [35S]GTPγS binding Assay	Rat	CHO-K1	[35S]GTPγS binding Assay
S01YF-1122-KX537	Magic™ Rat HRH3 in Vitro Radioligand Binding Assay	Rat	CHO-K1	Radioligand Binding Assay

Product Information

Target Protein

HRH3

Target Family

Histamine Family

Target Protein Species

Human

Host Cell Type

H975;H460;A549;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research

Related Diseases

Central Nervous System Disease;Kleine-Levin Hibernation Syndrome

Gene ID

Human: 11255

UniProt ID

Human: Q9Y5N1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Histamine receptor H3 (HRH3) has been associated with various diseases and conditions. Polymorphisms in the HRH3 gene have been linked to chronic heart failure in the Chinese Han population, suggesting its potential as a genetic marker for disease prediction and treatment. Additionally, the expression of HRH3 in brain endothelial cells has been studied, emphasizing its role in regulating brain capillary permeability.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Dorothy (Verified Customer)

How is the HRH3 gene expressed in brain endothelial cells? Apr 01 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Brain vascular endothelial cells express histamine H1 and H2 receptors, which regulate brain capillary permeability. It has been found that H3 and H4 receptors are also expressed in these cells, suggesting they may play a role in permeability regulation. Apr 01 2022

chat Helen (Verified Customer)

Are there any pharmacogenetic studies related to the HRH3 gene and its therapeutic implications? Apr 09 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Polymorphism of the HRH3 gene may be a potential genetic marker for predicting the therapeutic effect of the antipsychotic drug risperidone. Apr 09 2022

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