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  • mProX™ Human HRH1 Stable Cell Line

    [CAT#: S01YF-0923-PY87]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Protein
    HRH1
    Target Family
    Histamine Family
    Target Protein Species
    Human
    Host Cell Type
    THP-1;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Allergic Rhinitis;Chronic Urticaria
    Gene ID
    Human: 3269
    UniProt ID
    Human: P35367

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Histamine receptor H1 (HRH1) plays a significant role in various physiological and pathological processes. Recent studies have highlighted the potential of HRH1 as a target to enhance immunotherapy response. Specifically, the use of HRH1-specific antihistamines during immune checkpoint blockade (ICB) treatment has been associated with improved clinical outcomes, suggesting that HRH1-antihistamines may augment antitumor immunity. Additionally, research has delved into the methylation patterns of histamine receptor genes HRH1 and HRH2 in asthma patients, revealing the potential epigenetic mechanisms underlying asthma pathogenesis. These findings underscore the importance of HRH1 in both immunotherapy and respiratory diseases.

    Protocols

    Please visit our protocols page.

    Customer Reviews

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    FAQ

    chat Michelle (Verified Customer)

    Are there potential therapeutic implications of targeting HRH1 in pancreatic cancer? Jan 01 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, there is evidence suggesting that HRH1 enhances the malignant phenotype of pancreatic ductal adenocarcinoma (PDAC). Therefore, antihistamines targeting HRH1 might be repurposed as a therapy for PDAC. Jan 01 2020

    chat Kathleen (Verified Customer)

    How does HRH1 play a role in neurotransmitter system regulation, behavior, and neurogenesis in zebrafish? Oct 13 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    In zebrafish lacking the hrh1 gene, deficits in the dopaminergic and hypocretin systems have been observed during early development. However, these deficits appear to be compensated by the time the fish reach adulthood. Oct 13 2022
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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