mProX™ Human HCN1 Stable Cell Line
[CAT#: S01YF-1123-KX84]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
HCN1
Target Family
Hyperpolarization-activated, Cyclic Nucleotide-gated Channels
Target Protein Species
Human
Host Cell Type
PC12; CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
Cardiovascular Research; CNS Research
Related Diseases
Developmental And Epileptic Encephalopathy; Generalized Epilepsy With Febrile Seizures Plus, Type 10
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The first of four paralogous genes, HCN1, encodes the cyclic nucleotide-gated channels that are triggered by hyperpolarization. In the brain, HCN1 conducts a hyperpolarization-activated current. Neuronal firing and, when it occurs in excess, neuronal hyperexcitability are encouraged by the depolarization. Significantly, animal models of fever syndrome and febrile status epilepticus have been found to exhibit modified expression and function of HCN1. Five probands and four families with GEFS + symptoms were found to have incompletely penetrant, possibly pathogenic mutations in HCN1. Compared to de novo mutations that arise in transmembrane areas, variants linked to GEFS + typically impact non-transmembrane regions and have a milder impact on ion channel performance. There were also discovered four mutations of unknown importance outside transmembrane regions that could pose a concern. The customized HCN1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Ashley
I've been using the HCN1 cell line for my studies, and it has been an excellent choice.
Jan 08 2020
Verified Customer
Jason
The HCN1 cell line showed good performance in our hands. It was reliable for most experiments, and the customer support team was helpful in troubleshooting.
Jun 29 2020
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
