mProX™ Human HCK Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 HCK inhibition downregulates CXCR4/PI3K or MAPK pathways in leukemic cell lines.
HCK protein levels and mRNA expression in transduced leukemia cell extracts. The results of qRT-PCR were calculated and determined for each sample in relation to the endogenous gene's expression.
Ref: Roversi, Fernanda Marconi, et al. "Hematopoietic cell kinase (HCK) is a player of the crosstalk between hematopoietic cells and bone marrow niche through CXCL12/CXCR4 axis." Frontiers in cell and developmental biology 9 (2021): 634044.
Pubmed: 33842460
DOI: 10.3389/fcell.2021.634044
Research Highlights
Since of its crystal structure, HCK is a desirable target for therapy since it can both directly and indirectly block the proliferation of cancer cells and the alterations in the tumor microenvironment that promote tumor growth.
Poh, Ashleigh R., Robert JJ O'Donoghue, and Matthias Ernst. "Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells." Oncotarget 6.18 (2015): 15752.
Pubmed:
26087188
DOI:
10.18632/oncotarget.4199
A member of the Src family protein-tyrosine kinases (SFKs), hematopoietic cell kinase (HCK) is mostly expressed in myeloid and B lymphocyte lineage cells. The functions of HCK in glioblastoma (GBM) are yet to be investigated, nevertheless.
Wang, Zhenlin, et al. "HCK promotes glioblastoma progression by TGFβ signaling." Bioscience Reports 40.6 (2020): BSR20200975.
Pubmed:
32484210
DOI:
10.1042/BSR20200975
