mProX™ Human HCAR1 Stable Cell Line

[CAT#: S01YF-0923-PY150]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX545	Magic™ Mouse HCAR1 in Vitro cAMP Assay	Mouse	CHO-K1	cAMP Assay

Product Information

Target Protein

HCAR1

Target Family

Nicotinic Acid Family

Target Protein Species

Human

Host Cell Type

Anglne;HO8910PM;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Digestive and Renal Research;Metabolic Research

Related Diseases

Pellagra;Diversion Colitis

Gene ID

Human: 27198

UniProt ID

Human: Q9BXC0

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

HCAR1, a lactate receptor, has been identified to play a significant role in various physiological and pathological processes. Recent research has shown that lactate, through HCAR1, can act as a neuromodulator decreasing synaptic activity in both human and rodent brains, suggesting HCAR1 as a potential target for epilepsy treatment. Additionally, HCAR1 has been implicated in promoting tumor growth and progression in glioblastoma, emphasizing its potential as a therapeutic target. The receptor's involvement in regulating immune responses, as seen in sepsis attenuation, further underscores its importance in health and disease.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Christopher (Verified Customer)

How does HCAR1 influence neuronal network activity? Jul 17 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

HCAR1 activation in neurons leads to a reduction in neuronal activity through presynaptic mechanisms and by decreasing neuronal excitability. Jul 17 2023

chat Stephanie (Verified Customer)

Is there any connection between HCAR1 and mitochondrial functions? May 01 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

While HCAR1's direct association with mitochondrial functions isn't specified, proteins like Bcl-2 play a role in the inner mitochondrial membrane and can influence programmed cell death. May 01 2020

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