mProX™ Human GRIN1/GRIN2D Stable Cell Line

Product Information

Target Protein

GRIN1/GRIN2D

Target Family

Glutamate Receptor

Target Protein Species

Human

Host Cell Type

SW1990; PANC04.03; PANC1; CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

CNS Research

Related Diseases

Neurodevelopmental Disorder

Gene ID

2902

UniProt ID

Q05586

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human GRIN2D gene encodes the protein glutamate [NMDA] receptor subunit epsilon-4. Ionotropic glutamate receptors include the N-methyl-D-aspartate (NMDA) receptor class. Long-term potentiation, an activity-dependent improvement in synaptic transmission efficiency believed to underpin some forms of memory and learning, has been linked to the NMDA channel. The main receptor subunit NMDAR1 (GRIN1) and one or more of the four NMDAR2 subunits-NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D)-compose heteromers that make up NMDA receptor channels. The customized GRIN1/GRIN2D stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Jessica (Verified Customer)

Are there any known roles of GRIN1/GRIN2D in programmed cell death? Aug 10 2022

chat Sherry Smith (Creative Biolabs Scientific Support)

Direct associations between GRIN1/GRIN2D and programmed cell death aren't explicitly mentioned. Aug 10 2022

chat Michael (Verified Customer)

What are the potential applications of GRIN1/GRIN2D in tumor cell line research? Apr 22 2020

chat Sherry Smith (Creative Biolabs Scientific Support)

While the direct applications of GRIN1/GRIN2D in tumor cell line research aren't specified in the provided articles, extracellular vesicles from certain cell lines have shown broad and potent anti-tumor activity. Apr 22 2020

Published Data

Fig.1 GRIN2D was identified as an oncogene in PDAC.

Using western blot, we initially looked into GRIN2D expression in PDAC cells and discovered that it was overexpressed in a number of PDAC cell lines as compared to HPDE in non-tumor cell HPDE.

Ref: Wang, Jiatong, et al. "Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinoma." Biomarker Research 11.1 (2023): 74.

Pubmed: 37553583

DOI: 10.1186/s40364-023-00514-4

Research Highlights

A subset of ligand-gated ionotropic glutamate receptors called N-methyl-d-aspartate receptors (NMDARs) is essential for memory, learning, and neural growth. On the other hand, epilepsy is one of the many neuropathological disorders that can arise from mutations in NMDAR subunits.
Camp, Chad R., and Hongjie Yuan. "GRIN2D/GluN2D NMDA receptor: Unique features and its contribution to pediatric developmental and epileptic encephalopathy." European Journal of Paediatric Neurology 24 (2020): 89-99.
Pubmed: 31918992 DOI: 10.1016/j.ejpn.2019.12.007

The ligand-gated ionotropic receptors known as N-methyl d-aspartate receptors mediate a sluggish, calcium-permeable portion of excitatory synaptic transmission in the central nervous system. Numerous neurodevelopmental diseases have been linked to variations in the genes encoding NMDAR subunits.
XiangWei, Wenshu, et al. "Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy." Brain 142.10 (2019): 3009-3027.
Pubmed: 31504254 DOI: 10.1093/brain/awz232