mProX™ Human GPR85 Stable Cell Line

Breton TS, et al. "Characterizing the SREB G protein-coupled receptor family in fish: Brain gene ." Comparative biochemistry and physiology. Part A, Molecular & integrative , 2023.
SREB1 (orphan designation GPR27), SREB2 (GPR85), and SREB3 (GPR173) are a family of receptors associated with various processes, including neuronal plasticity and reproductive control. The similarities between these receptors, as well as their comparison to non-mammalian vertebrates, are not well understood. In certain fish species, the complexity of this system is further complicated by the presence or absence of a fourth member (SREB3B). To gain a better understanding of this system, a study was conducted using qPCR to examine sreb and related gene expression patterns in the brains of three fish species. The study also aimed to identify differences in transcriptional regulation among the receptors using upstream transcription factor binding sites in 70 ray-finned fish genomes. The results showed that sreb expression was regionally abundant in forebrain-related areas, with some species-specific patterns observed. Notably, zebrafish (Danio rerio) displayed higher expression of receptors in hypothalamic-containing sections, and pufferfish (Dichotomyctere nigroviridis) showed divergence between sreb3a and sreb3b. Additionally, a gene (dkk3a) related to this system was found to be spatially correlated with the receptors in all three species. Analysis of the genomic regions upstream of sreb2 and sreb3b revealed a high number of conserved transcription factor binding sites. These findings provide valuable insights into the expression and transcriptional regulation of these receptors in fish, which could aid in further research to enhance our understanding of their functions.
Pubmed: 37611891   DOI: 10.1016/j.cbpa.2023.111507

Lu Y, et al. "Molecular insights into orphan G protein-coupled receptors relevant to ." British journal of pharmacology, 2023.
The relationship between schizophrenia and GPR3, GPR6, GPR12, GPR52, GPR85, GPR88 and GPR139 has been extensively studied. The expression, signalling mechanisms, and cellular function of these receptors have been thoroughly reviewed, along with the development of small molecules and structural insights. A comprehensive overview of the emerging evidence and potential for new schizophrenia therapeutics is presented. The collective findings suggest promising avenues for further research and therapeutic interventions.
Pubmed: 37605621   DOI: 10.1111/bph.16221