mProX™ Human GPR65 Stable Cell Line

[CAT#: S01YF-0923-PY172]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

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Lot Number

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX804	Magic™ Mouse GPR65 in Vitro cAMP Assay	Mouse	1321N1	cAMP Assay
S01YF-1122-KX805	Magic™ Rat GPR65 in Vitro cAMP Assay	Rat	1321N1	cAMP Assay

Product Information

Target Protein

GPR65

Target Family

Orphan Family

Target Protein Species

Human

Host Cell Type

HeLa;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research

Related Diseases

Gastric Cancer;Aleutian Mink Disease

Gene ID

Human: 8477

UniProt ID

Human: Q8IYL9

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

GPR65, also known as TDAG8, is a proton-sensing G-protein-coupled receptor that plays a pivotal role in various inflammatory processes. It has been identified as a key regulator in the pathogenesis of inflammatory bowel disease (IBD), where it modulates Th1 and Th17 cell immune responses. Furthermore, GPR65 has been associated with the suppression of intestinal inflammation and the development of colitis-associated tumors in murine models. The receptor's role in skin health has also been explored, where it has been shown that carbon dioxide can suppress skin inflammation by activating GPR65 in human keratinocytes.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Christopher (Verified Customer)

What is the significance of GPR65 in immune response? Jan 29 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR65, also known as T-cell death-associated gene 8 (TDAG8), is known to be involved in immune responses. It plays a role in T-cell apoptosis and might help in regulating immune responses. The receptor is sensitive to pH changes, which is crucial for immune cell trafficking during inflammatory responses. Jan 29 2023

chat Timothy (Verified Customer)

How does GPR65 regulate pH sensitivity? Jun 06 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR65 is a proton-sensing G-protein-coupled receptor, which gets activated in acidic environments. This is particularly relevant in inflammatory conditions where the local environment becomes acidic. Through its pH-sensing ability, GPR65 can modulate immune cell functions. Jun 06 2020

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