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    mProX™ Human GPR50 Stable Cell Line

    [CAT#: S01YF-0923-PY166]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GPR50
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    HepG2;SNU475;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Pituitary Adenoma 2, Growth Hormone-Secreting;Major Depressive Disorder
    Gene ID
    Human: 9248
    UniProt ID
    Human: Q13585

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR50, an orphan G-protein-coupled receptor, has been associated with various physiological processes. It has been linked to the regulation of melatonin-related receptors, but no significant association has been found between mutations in GPR50 and adolescent idiopathic scoliosis. In the context of cellular processes, GPR50 has been shown to attenuate inflammation and insulin signaling in preadipocytes, suggesting its potential role in metabolic regulation. Additionally, GPR50 has been implicated in oocyte maturation, indicating its significance in reproductive biology. Furthermore, research has highlighted GPR50's involvement in cell cycle regulation, particularly in the G1/S-phase transition.

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    FAQ

    chat Michelle (Verified Customer)

    Are there any known interactions of GPR50 with other receptors in cell lines? Aug 15 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, GPR50 has been found to interact with TGFβ receptor type I (TβRI) in breast cancer cell lines, leading to activation of TβRI and subsequent signaling pathways associated with cancer pathophysiology. Aug 15 2021

    chat Gary (Verified Customer)

    What therapeutic insights have been derived from studying GPR50 expression in cell lines? Jul 10 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Studies of GPR50 expression in cell lines have revealed its potential role in cancer progression and provided insights into possible targeted therapies. For instance, GPR50's interaction with TGFβ receptor suggests a pathway that may be targeted in cancer treatment. Jul 10 2021

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    • mProX™ Human GPR50 Stable Cell Line (CAT#: S01YF-0923-PY166)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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