mProX™ Human GPR45 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Gpr45 knockdown in primary hypothalamus cells resulted in Pomc downregulation.
In primary hypothalamic cells, the suppression of Gpr45 led to a notable decrease in Pomc expression levels. The results are presented as the mean ± SEM, with statistical significance indicated by asterisks (*P < 0.05, **P < 0.01, and ***P < 0.001) as determined through Student's t-test analysis.
Ref: Cui, Jing, et al. "Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity." The Journal of clinical investigation 126.9 (2016): 3192-3206.
Pubmed: 27500489
DOI: 10.1172/JCI85676
Research Highlights
Tsai MC, et al. "Genome-wide association study of age at menarche in the Taiwan Biobank suggests ." Journal of human genetics, 2023.
The process of sexual maturation is an intricate physiological process that is influenced by various factors, including genetic and environmental elements. In females, the age at which they experience their first menstruation, also known as menarche (AM), is a crucial milestone in sexual maturation. This study, utilizing data from a national population cohort in Taiwan, aimed to identify genetic markers associated with AM. Through a genome-wide association study and meta-analysis, four significant loci - LIN28B, NOL4, GPR45, and LOC105373831 - were found to be linked with AM. Further analyses also revealed LIN28B, NOL4, RXRG, ETV5, and HACE1 as significantly associated genes, while a specific genetic pathway involving the mTOR signaling complex showed enrichment. The study also identified a new genetic marker, rs7239368 in NOL4, that was associated with AM in the Taiwanese female population. Further research is needed to validate its role in sexual maturation.
Pubmed:
36710296
DOI:
10.1038/s10038-023-01124-6
Tsai MC, et al. "Identification of genetic risk loci for depression and migraine comorbidity in ." Frontiers in psychiatry, 2022.
The genetic association between depression and migraine in Asian populations has not been extensively studied. The underlying genetic factors for comorbid depression and different types of migraine remain unclear. Therefore, a study was conducted in Taiwan to investigate susceptibility loci associated with depression and migraine comorbidity in the Han Chinese population. The study involved 966 participants with migraine, with or without depression, and genotyping was performed using their genomic DNA. Results suggest that several genetic variants, including CDH4 intron region (rs78063755), NTRK3-AS1 downstream region (rs57729223), and between LINC01918 and GPR45 (rs2679891), may be suggestive of an association with depression. Additionally, 20 more susceptibility loci were identified within specific subgroups of migraine. Furthermore, a specific variant in the CDH4 intron region (rs78063755) was found to be associated with both Beck Depression Inventory and Migraine Disability Assessment scores. These findings provide potential genetic candidates for further research on the genetic basis of depression and migraine comorbidity in the Han Chinese population.
Pubmed:
36704746
DOI:
10.3389/fpsyt.2022.1067503
