mProX™ Human GPR4 Stable Cell Line

[CAT#: S01YF-0923-PY171]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX800	Magic™ Mouse GPR4 in Vitro cAMP Assay	Mouse	1321N1	cAMP Assay
S01YF-1122-KX801	Magic™ Rat GPR4 in Vitro cAMP Assay	Rat	1321N1	cAMP Assay

Product Information

Target Protein

GPR4

Target Family

Orphan Family

Target Protein Species

Human

Host Cell Type

HBMECs;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research

Related Diseases

Prolactin Producing Pituitary Tumor;Central Sleep Apnea

Gene ID

Human: 2828

UniProt ID

Human: P46093

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

GPR4, a proton-activated G-protein-coupled receptor, has been recognized for its role in various physiological processes. It has been associated with the development of osteoarthritis, where it modulates CXCL12/CXCR7 signaling. Furthermore, GPR4 has been implicated in the pH-dependent migration of melanoma cells within the tumor microenvironment. In the context of cardiovascular health, GPR4 has been suggested as a potential therapeutic target for COVID-19, where it might mitigate hyper-inflammatory responses and associated complications. Additionally, GPR4's role in regulating blood pressure and cardiovascular risk has been explored, emphasizing the importance of dietary fiber in modulating its activity.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Donna (Verified Customer)

How is GPR4 related to inflammatory responses? Feb 19 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR4 mediates tissue edema, inflammatory exudate formation, and leukocyte infiltration in inflamed tissue, playing a role in inflammatory responses, particularly in osteoarthritis. Feb 19 2022

chat Laura (Verified Customer)

Can GPR4 be studied using stable cell lines? Nov 15 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, there are stable cell lines like the B16/GPR4 cell line, which is a stable GPR4-overexpressing cell line, used to investigate GPR4's role in melanoma cell spreading and adhesion. Additionally, HEK293 cells have been utilized to study GPR4 expression and function. Nov 15 2021

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