mProX™ Human GPR37L1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 In primary astrocytes, complete prosaposin safeguards cellular integrity by stimulating GPR37 and GPR37L1 receptors, thereby ensuring their overall well-being and functionality.
In the investigation involving HEK-293T cells, which were momentarily transfected with an empty vector (designated as "Mock"), GPR37/syntenin-1, or GPR37L1, and then treated with prosaposin (at a concentration of 100 nM for 10 minutes), a notable increase in ERK phosphorylation was observed solely in the cells transfected with GPR37 or GPR37L1. This finding was consistent across three independent experiments, each conducted in duplicate, and displayed statistical significance with a p-value of less than 0.001 (***P < 0.001).
Ref: Meyer, Rebecca C., et al. "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin." Proceedings of the National Academy of Sciences 110.23 (2013): 9529-9534.
Pubmed: 23690594
DOI: 10.1073/pnas.1219004110
Research Highlights
Wu Z, et al. "Single-cell analysis of spinal cord injury reveals functional heterogeneity of ." Gene, 2023.
The study of spinal cord injury (SCI) is focused on understanding the destruction of myelin and neuronal death, which are difficult to reverse. Oligodendrocyte progenitor cells and oligodendrocytes play crucial roles in maintaining myelin and aiding in axon regeneration. However, there is limited research on the communication and status of these cells after an injury. The advancement in single-cell sequencing technology allowed researchers to examine the specific changes and interactions of oligodendrocyte lineage cells at various time points after SCI. The study revealed the importance of Psap (Prosaposin)/Gpr37l1 and Psap/Gpr37 ligand-receptor pairs in these cells, as well as potential transcription factors like Junb. This study provides insights into the transcriptional mechanisms of oligodendrocytes and identifies potential targets for further research.
Pubmed:
37579960
DOI:
10.1016/j.gene.2023.147713
Breitwieser GE, et al. "Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders.." bioRxiv : the preprint server for biology, 2023.
In recent years, there has been an increased focus on G-protein coupled receptors (GPCRs) as potential targets for drug development due to their involvement in a range of diseases. Despite this, a significant number of GPCRs known as orphan receptors remain poorly understood and have no known ligands or functions. To address this gap in knowledge, recent research has utilized rare variant analyses and functional studies in cellular and animal models to identify potential roles for orphan receptors in health and disease. Through this approach, a novel drug target has been identified for the treatment of neurological disorders with limited treatment options.
Pubmed:
37461723
DOI:
10.1101/2023.07.05.547546
