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    mProX™ Human GPR37 Stable Cell Line

    [CAT#: S01YF-0923-PY190]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GPR37
    Target Family
    Orphan Family
    Target Protein Species
    Mouse
    Host Cell Type
    MC-38;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Ocular Research;CNS Research
    Related Diseases
    Juvenile-Onset Parkinson's Disease;Epilepsy, Familial Temporal Lobe, 6
    Gene ID
    Mouse: 14763
    UniProt ID
    Mouse: Q9QY42

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR37, a G protein-coupled receptor, has been associated with various neurological processes. Recent research has highlighted its protective role against infection-induced sepsis and pain-like behavior in mice. Additionally, GPR37's involvement in the progression of lung adenocarcinoma has been documented, suggesting its potential as a therapeutic target. The receptor's role in regulating oligodendrocyte differentiation and myelination in the central nervous system further underscores its significance in neurological health. Moreover, GPR37 has been linked to Parkinson's disease, making it a potential biomarker for this neurodegenerative condition.

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    FAQ

    chat Jennifer (Verified Customer)

    What is the role of GPR37 in cellular functions? Jun 23 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR37, a G protein-coupled receptor, is implicated in various cellular functions. When properly folded and trafficked to the plasma membrane, it exhibits a protective role against dopaminergic toxins in certain cell types like N2a neuroblastoma cells. Moreover, the subcellular distribution of GPR37 affects cell viability, where its accumulation and aggregation within the cell can cause cell death, while its presence in the plasma membrane provides cell protection​​. Jun 23 2022

    chat Jessica (Verified Customer)

    What are the potential research applications of GPR37 custom cell line products? Oct 29 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR37 custom cell line products can serve as invaluable tools in studying the molecular mechanisms underlying GPR37's function and its role in cell viability and protection against certain toxins. These custom cell lines enable researchers to delve into the receptor's interactions with other proteins and molecules, its trafficking to the plasma membrane, and its implication in diseases such as parkinsonism. Additionally, GPR37 custom cell lines can aid in drug discovery efforts aimed at modulating GPR37 activity or preventing its intracellular aggregation, potentially offering therapeutic strategies for related neurological conditions​​. Oct 29 2021

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    • mProX™ Human GPR37 Stable Cell Line (CAT#: S01YF-0923-PY190)
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