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  • mProX™ Human GPR35 Stable Cell Line

    [CAT#: S01YF-0923-PY165]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Protein
    GPR35
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    LS174T;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research;Digestive and Renal Research
    Related Diseases
    Cholangitis, Primary Sclerosing;Microphthalmia, Isolated 1.
    Gene ID
    Human: 2859
    UniProt ID
    Human: Q9HC97

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR35 has been identified as a receptor that plays a role in various physiological processes. It promotes neutrophil recruitment in response to the serotonin metabolite 5-HIAA. Additionally, GPR35 activation has been linked to angiogenesis in the tumor microenvironment. This receptor's structural insights have also been explored, revealing its unique ligand recognition mode and potential as a therapeutic target.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Jennifer (Verified Customer)

    How does GPR35 expression impact lipid metabolism in hepatocyte cell lines? Apr 27 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    In hepatocyte cell lines, GPR35 expression has been shown to suppress lipid accumulation, which can be critical in studying and understanding metabolic disorders and potential treatments​​. Apr 27 2023

    chat Jason (Verified Customer)

    Are there known ligands for GPR35 that affect its activity in cell lines? Dec 17 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, GPR35 has been shown to be activated by metabolites such as tryptophan-derived kynurenic acid (KYNA), chemokine CXCL17, and phospholipid derivate lysophosphatidic acid (LPA) species, which could be studied further using stable cell lines expressing GPR35​​. Dec 17 2022
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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