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    mProX™ Human GPR25 Stable Cell Line

    [CAT#: S01YF-0923-PY184]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GPR25
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1
    Target Classification
    GPCR Cell Lines
    Gene ID
    Human: 2848
    UniProt ID
    Human: O00155

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR25, another member of the G-protein coupled receptor family, has been studied in non-mammalian vertebrates. Research has shown that in species such as zebrafish, spotted gars, and pigeons, GPR25 can be activated by Apelin and Apela peptides, which are also endogenous ligands of the vertebrate Apelin receptor (APLNR). This suggests that GPR25 might have conserved functions across different species and could play a role in various physiological processes. Further studies are needed to elucidate the specific roles and potential therapeutic applications of GPR25.

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    FAQ

    chat Barbara (Verified Customer)

    What is the significance of GPR25 in cellular research? Mar 20 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR25 is an orphan G protein-coupled receptor (GPCR) in vertebrates and has been associated with autoimmune diseases and the regulation of blood pressure in humans. The receptor activates signaling cascades in response to extracellular stress. Although it holds potential for understanding and treating related health conditions, the endogenous ligand of GPR25 remains unidentified in vertebrates, which is a common challenge with orphan GPCRs​​. Mar 20 2020

    chat Michael (Verified Customer)

    What are the challenges and prospects in GPR25 research? Oct 31 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    One of the primary challenges in GPR25 research is the lack of knowledge regarding its endogenous ligand, which hampers the full understanding of its biological function. However, the association of GPR25 with autoimmune diseases and blood pressure regulation presents a significant avenue for research. Utilizing stable cell line products to study GPR25 can help overcome some of these challenges by providing a controlled system to investigate the receptor's function and signaling pathways, which could eventually lead to the identification of its ligand and the development of therapeutic strategies for related health conditions​. Oct 31 2021

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    • mProX™ Human GPR25 Stable Cell Line (CAT#: S01YF-0923-PY184)
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