mProX™ Human GPR173 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 The inhibition of GPR173 resulted in the elimination of the beneficial effects of phoenixin-14 in mitigating NLRP3 inflammasome activation induced by LPS.
Inhibiting GPR173 effectively nullified the impact of PNX-14 on both NLRP3 expression and the secretion of IL-18 and IL-1β. Consequently, PNX-14 demonstrated its ability to hinder the activation of the NLRP3 inflammasome induced by LPS, with GPR173 serving as a crucial mediator in this process (significant difference denoted by $, &, *, P<0.01 compared to the preceding column group; n=5).
Ref: Wang, Jian, et al. "The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes." Inflammation Research 69 (2020): 779-787.
Pubmed: 32435966
DOI: 10.1007/s00011-020-01355-9
Research Highlights
Mlyczynska E, et al. "Phoenixin-14 as a novel direct regulator of porcine luteal cell functions.." Biology of reproduction, 2023.
The neuropeptide Phoenixin (PNX) is known for its role in regulating reproductive processes in the central nervous system, but its role in the ovary has not been extensively studied. This study focuses on the active PNX isoform, PNX-14, which acts through the G protein-coupled receptor 173 (GPR173). The researchers hypothesized that PNX-14 is produced in the porcine corpus luteum (CL) and can affect its endocrine function by acting on GPR173 and protein kinase signaling. Cultured luteal cells were used to investigate the effects of PNX-14, showing that both PNX-14 and GPR173 are produced locally in the porcine CL and their levels change during the estrous cycle. PNX-14 was found in the cytoplasm, while GPR173 was found in the cell membrane. PNX levels were highest during the early luteal phase in plasma. Additionally, the researchers found that PNX-14 affected the secretion of hormones and enzymes related to luteal function and influenced the expression and activity of several protein kinases. These results suggest that PNX is produced by luteal cells and may play a role in regulating their function.
Pubmed:
37815939
DOI:
10.1093/biolre/ioad138
Breton TS, et al. "Characterizing the SREB G protein-coupled receptor family in fish: Brain gene ." Comparative biochemistry and physiology. Part A, Molecular & integrative , 2023.
The study aims to characterize the expression patterns of SREB1 (orphan designation GPR27), SREB2 (GPR85), and SREB3 (GPR173) in the brains of three different fish species using qPCR. The research also looks at the transcriptional regulation of these receptors by analyzing upstream transcription factor binding sites across 70 ray-finned fish genomes. It was found that while regional expression patterns were similar across all species, there were some species-specific differences, such as the expression of receptors in the hypothalamus of zebrafish and the divergence between SREB3A and SREB3B in pufferfish. The results provide valuable insight into the expression and regulation of these receptors in fish and may guide future research.
Pubmed:
37611891
DOI:
10.1016/j.cbpa.2023.111507
