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  • mProX™ Human GPR171 Stable Cell Line

    [CAT#: S01YF-0923-PY177]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GPR171
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    Neuro2A;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Gene ID
    Human: 29909
    UniProt ID
    Human: O14626

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR171 has been recognized for its role in modulating pain signals. Activation of GPR171 has shown potential in alleviating chronic neuropathic and inflammatory pain. Moreover, GPR171's function as a co-inhibitor of T cell signaling suggests its potential application in cancer immunotherapy. The exploration of GPR171's therapeutic potential, especially in pain management and oncology, holds promise for future medical interventions.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Kimberly (Verified Customer)

    What role does GPR171 play in immune response? Sep 19 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR171 is implicated in T cell activation, where it acts to suppress T cell activation, indicating a potential role in immune response regulation​. Sep 19 2021

    chat Michael (Verified Customer)

    How is GPR171 associated with the hematopoietic system? Jan 03 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR171 is a G-protein-coupled receptor related to the P2Y family of purinergic receptors, which have been shown to regulate hematopoietic progenitor cells​. Jan 03 2023

    Published Data

    Fig.1 When GPR171 expression is diminished or obstructed, it leads to a notable attenuation in the signal transmission mediated by BigLEN.

    The heightened expression of GPR171 results in a substantial elevation in specific [125I]Tyr-BigLEN binding within Neuro2A cells, while the introduction of shRNA targeting GPR171 leads to a marked reduction in binding compared to Neuro2A cells (p < 0.0001).

    Ref: Gomes, Ivone, et al. "GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding." Proceedings of the National Academy of Sciences 110.40 (2013): 16211-16216.

    Pubmed: 24043826

    DOI: 10.1073/pnas.1312938110

    Research Highlights

    Baalmann F, et al. "Reduced urine volume and changed renal sphingolipid metabolism in ." Frontiers in cell and developmental biology, 2023.
    The UDP-glucose receptor P2RY14, a rhodopsin-like G protein-coupled receptor (GPCR), has been previously described as a receptor expressed in A-intercalated cells of the mouse kidney. Recent studies have shown that P2RY14 is also abundantly expressed in the collecting duct principal cells of the papilla and the epithelial cells lining the renal papilla. To gain a better understanding of its role in the kidney, a P2ry14 reporter and gene-deficient (KO) mouse strain were utilized. Morphometric analysis revealed that P2RY14 contributes to kidney morphology, as KO mice had a broader cortex compared to wild-type (WT) mice. In addition, the outer stripe of the outer medulla was larger in WT mice than KO mice. Transcriptome comparison of WT and KO mice showed differences in gene expression, including extracellular matrix proteins and proteins involved in sphingolipid metabolism and other GPCRs. Mass spectrometry analysis revealed changes in sphingolipid composition in the renal papilla of KO mice. At the functional level, KO mice had a reduced urine volume but an unchanged glomerular filtration rate under normal chow and salt diets. This study highlights the importance of P2RY14 in the collecting duct principal cells and cells lining the renal papilla, and suggests a potential role in nephroprotection through the regulation of decorin.
    Pubmed: 37250906   DOI: 10.3389/fcell.2023.1128456

    McDermott MV, et al. "A small molecule ligand for the novel pain target, GPR171, produces minimal ." Pharmacology, biochemistry, and behavior, 2023.
    The drug MS15203, which activates the receptor GPR171, has been demonstrated to enhance the effectiveness of morphine in relieving pain. Through the use of in vivo and histological methods, the authors have shown that MS15203 does not activate the reward circuitry in rodents, further supporting its potential as a novel pain medication and GPR171 as a potential pain target. These findings suggest that more research should be conducted on MS15203 for pain management.
    Pubmed: 36933620   DOI: 10.1016/j.pbb.2023.173543

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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