mProX™ Human GPR17 Stable Cell Line

Product Information

Target Protein

GPR17

Target Family

Orphan Family

Target Protein Species

Human

Host Cell Type

Primary;neurons;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research

Related Diseases

Periventricular Leukomalacia;Encephalomalacia

Gene ID

Human: 2840

UniProt ID

Human: Q13304

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

GPR17, a G-protein coupled receptor, has been identified as a potential therapeutic target in various neurological and inflammatory conditions. Recent studies have unveiled its role in the self-activation process, where the extracellular loop2 of GPR17 occupies the orthosteric binding pocket. This receptor is intricately involved in the myelination process, inhibiting the maturation of oligodendrocyte progenitor cells into myelinating oligodendrocytes. Furthermore, GPR17 has been associated with CXCR2 or CxCR4, suggesting its potential role in the development of the neuroinflammatory milieu associated with demyelinating events. In the realm of oncology, GPR17 signaling has been linked to glioblastoma, where its activation induces cell death via modulation of the MAPK pathway.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Nancy (Verified Customer)

What is the function of GPR17? Mar 27 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR17 is a G-protein-coupled receptor (GPCR) known to be involved in the regulation of oligodendrocyte differentiation and myelination processes in the central nervous system. It acts as a regulator in the maturation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes. It is crucial for the development and function of the central nervous system. Mar 27 2022

chat Jessica (Verified Customer)

Are there any known ligands for GPR17? Jul 14 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, uracil nucleotides and cysteinyl leukotrienes have been identified as ligands for GPR17. The receptor acts as a sensor for these ligands, and their binding can activate downstream signaling pathways. Jul 14 2020

mProX™ Human GPR17 Stable Cell Line

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