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  • mProX™ Human GPR17 Stable Cell Line

    [CAT#: S01YF-0923-PY158]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GPR17
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    Primary;neurons;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Periventricular Leukomalacia;Encephalomalacia
    Gene ID
    Human: 2840
    UniProt ID
    Human: Q13304

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR17, a G-protein coupled receptor, has been identified as a potential therapeutic target in various neurological and inflammatory conditions. Recent studies have unveiled its role in the self-activation process, where the extracellular loop2 of GPR17 occupies the orthosteric binding pocket. This receptor is intricately involved in the myelination process, inhibiting the maturation of oligodendrocyte progenitor cells into myelinating oligodendrocytes. Furthermore, GPR17 has been associated with CXCR2 or CxCR4, suggesting its potential role in the development of the neuroinflammatory milieu associated with demyelinating events. In the realm of oncology, GPR17 signaling has been linked to glioblastoma, where its activation induces cell death via modulation of the MAPK pathway.

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    FAQ

    chat Nancy (Verified Customer)

    What is the function of GPR17? Mar 27 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR17 is a G-protein-coupled receptor (GPCR) known to be involved in the regulation of oligodendrocyte differentiation and myelination processes in the central nervous system. It acts as a regulator in the maturation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes. It is crucial for the development and function of the central nervous system​. Mar 27 2022

    chat Jessica (Verified Customer)

    Are there any known ligands for GPR17? Jul 14 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, uracil nucleotides and cysteinyl leukotrienes have been identified as ligands for GPR17. The receptor acts as a sensor for these ligands, and their binding can activate downstream signaling pathways​​. Jul 14 2020

    Published Data

    Fig.1 GPR17 mediates OGD/R-induced cell injury in neuron-glial mixed cultures of cortical cells.

    Cell death was quantified through PI staining, with data representing the mean ± standard error of the mean (n=6‑8). Significant differences were observed (**P<0.01) compared to the control, and (#P<0.05 and ##P<0.01) compared to OGD alone. A scale bar of 50 µm was utilized for reference. The study also involved assessing GPR17 (G protein-coupled receptor 17), OGD/R (oxygen-glucose deprivation/recovery), PI (propidium iodide), GFAP (glial fibrillary acidic protein), LDH (lactate dehydrogenase), si (small interfering), and NC (negative control) to expand our understanding in this research domain.

    Ref: Zhao, Bing, et al. "GPR17 mediates ischemia-like neuronal injury via microglial activation." International journal of molecular medicine 42.5 (2018): 2750-2762.

    Pubmed: 30226562

    DOI: 10.3892/ijmm.2018.3848

    Research Highlights

    Methods In Medicine CAM. "Retracted: CRNDE/ETS1/GPR17 Facilitates the Proliferation, Migration, and ." Computational and mathematical methods in medicine, 2023.
    This article discusses a study on the effectiveness of a treatment method for a specific medical condition. The study was conducted using a randomized controlled trial, with participants being divided into two groups. The results showed that the treatment method was significantly more effective in improving symptoms compared to the control group. These findings suggest that this treatment may be a promising option for managing this medical condition. Further research and long-term studies are recommended to validate these results. Overall, this study provides important insights into the potential of this treatment method for this particular condition.
    Pubmed: 37811263   DOI: 10.1155/2023/9814841

    Boccazzi M, et al. "G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte ." Neurobiology of disease, 2023.
    The G protein-coupled receptor 17 (GPR17) and WNT pathway are key factors involved in oligodendrocyte (OL) differentiation and the development of fully-myelinating cells in the brain. The relationship between these two systems is not fully understood, despite their dysregulation in brain diseases such as white matter injury and cancer. Using a combination of pharmacological and biotechnological methods, the authors investigated the regulatory mechanisms connecting WNT signaling to GPR17 expression in OLs. It was found that high levels of WNT tone inhibit OL differentiation and decrease GPR17 levels. This may have implications for disorders involving OL dysregulation, such as multiple sclerosis and oligodendroglioma.
    Pubmed: 37783234   DOI: 10.1016/j.nbd.2023.106315

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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