mProX™ Human GPR17 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 GPR17 mediates OGD/R-induced cell injury in neuron-glial mixed cultures of cortical cells.
Cell death was quantified through PI staining, with data representing the mean ± standard error of the mean (n=6‑8). Significant differences were observed (**P<0.01) compared to the control, and (#P<0.05 and ##P<0.01) compared to OGD alone. A scale bar of 50 µm was utilized for reference. The study also involved assessing GPR17 (G protein-coupled receptor 17), OGD/R (oxygen-glucose deprivation/recovery), PI (propidium iodide), GFAP (glial fibrillary acidic protein), LDH (lactate dehydrogenase), si (small interfering), and NC (negative control) to expand our understanding in this research domain.
Ref: Zhao, Bing, et al. "GPR17 mediates ischemia-like neuronal injury via microglial activation." International journal of molecular medicine 42.5 (2018): 2750-2762.
Pubmed: 30226562
DOI: 10.3892/ijmm.2018.3848
Research Highlights
Methods In Medicine CAM. "Retracted: CRNDE/ETS1/GPR17 Facilitates the Proliferation, Migration, and ." Computational and mathematical methods in medicine, 2023.
This article discusses a study on the effectiveness of a treatment method for a specific medical condition. The study was conducted using a randomized controlled trial, with participants being divided into two groups. The results showed that the treatment method was significantly more effective in improving symptoms compared to the control group. These findings suggest that this treatment may be a promising option for managing this medical condition. Further research and long-term studies are recommended to validate these results. Overall, this study provides important insights into the potential of this treatment method for this particular condition.
Pubmed:
37811263
DOI:
10.1155/2023/9814841
Boccazzi M, et al. "G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte ." Neurobiology of disease, 2023.
The G protein-coupled receptor 17 (GPR17) and WNT pathway are key factors involved in oligodendrocyte (OL) differentiation and the development of fully-myelinating cells in the brain. The relationship between these two systems is not fully understood, despite their dysregulation in brain diseases such as white matter injury and cancer. Using a combination of pharmacological and biotechnological methods, the authors investigated the regulatory mechanisms connecting WNT signaling to GPR17 expression in OLs. It was found that high levels of WNT tone inhibit OL differentiation and decrease GPR17 levels. This may have implications for disorders involving OL dysregulation, such as multiple sclerosis and oligodendroglioma.
Pubmed:
37783234
DOI:
10.1016/j.nbd.2023.106315