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    mProX™ Human GPR149 Stable Cell Line

    [CAT#: S01YF-1023-PY311]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Mouse
    Host Cell Type
    Oligodendrocyte precursor cells;CHO-K1;HEK293
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Gene ID
    Human:344758
    UniProt ID
    Human:Q86SP6

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR149 is another orphan G protein-coupled receptor that has garnered attention in the scientific community. Recent studies have highlighted its potential role in myelination processes. Specifically, GPR149 has been shown to act as a negative regulator of myelination and remyelination, suggesting its involvement in demyelinating diseases. Additionally, GPR149 has been linked to diabetic nephropathy, a complication of diabetes that affects the kidneys. Moreover, methylation patterns of GPR149 have been proposed as potential prognostic markers for clear cell renal cell carcinoma. These findings underscore the importance of GPR149 in various physiological and pathological contexts.

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    FAQ

    chat Donna (Verified Customer)

    How does GPR149 influence myelination processes? Jan 15 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR149 acts as a negative regulator of myelination and remyelination. Its expression is downregulated during the differentiation of oligodendrocyte precursor cells (OPCs) into oligodendrocytes (OLs). GPR149 deficiency promotes OPC to OL differentiation, leading to earlier myelin development. Jan 15 2022

    chat Ashley (Verified Customer)

    What role does GPR149 play in fertility? May 01 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR149 is an oocyte-enriched gene. Deletion of GPR149 in mice has been shown to lead to increased fertility. Specifically, high levels of GPR149 expression were observed in germinal vesicle and meiosis II stage oocytes. May 01 2020

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    • mProX™ Human GPR149 Stable Cell Line (CAT#: S01YF-1023-PY311)
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