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    mProX™ Human GPR143 Stable Cell Line

    [CAT#: S01YF-1023-PY308]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    MCF-7;CHO-K1;HEK293
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research;Ocular Research
    Related Diseases
    Albinism, Ocular, Type I;Nystagmus 6, Congenital, X-Linked
    Gene ID
    Human:4935
    UniProt ID
    Human:P51810

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR143, also known as G Protein-Coupled Receptor 143, is notably associated with ocular albinism. Recent studies have shown that L-DOPA and its receptor, GPR143, regulate neurogenesis in the dentate gyrus (DG) in a dopamine-independent manner, playing a role in mood regulation in the hippocampus. Furthermore, research has highlighted the potential of CRISPR-AsCas12a in correcting a GPR143 intronic mutation in induced pluripotent stem cells from an ocular albinism patient. The diverse roles of GPR143 in various physiological processes make it a promising target for therapeutic interventions.

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    FAQ

    chat Amy (Verified Customer)

    How does GPR143 influence exosome biogenesis and cancer metastasis? Jun 26 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR143 plays a pivotal role in controlling ESCRT-dependent exosome biogenesis. Elevated levels of GPR143 have been observed in multiple cancers. The GPR143-ESCRT pathway promotes the secretion of exosomes with unique cargo, including integrins signaling proteins, which may further contribute to cancer metastasis. Jun 26 2021

    chat Jessica (Verified Customer)

    What is the connection between GPR143 and vision? May 24 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR143 is involved in pigmentation processes, and its role in vision has been explored. Research suggests that GPR143 may have a regulatory role in vision, potentially influencing visual pathways and responses. May 24 2020

    Related Products by Target
    • mProX™ Human GPR143 Stable Cell Line (CAT#: S01YF-1023-PY308)
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