mProX™ Human GPR135 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 P59 showed no ability to activate a cAMP response in GPR135-transfected cells.
cAMP stimulation with a dose-response curve. GPR135-transfected cells were exposed to increasing quantities of relaxin 3 (as a positive control, H3 relaxin) and P59. In comparison to H3 relaxin, P59 had no effect on GPR135. Relaxin is depicted by circles, while P59 is represented by triangles.
Ref: Shemesh, Ronen, et al. "Activation of relaxin-related receptors by short, linear peptides derived from a collagen-containing precursor." Annals of the New York Academy of Sciences 1160.1 (2009): 78-86.
Pubmed: 19416163
DOI: 10.1111/j.1749-6632.2009.03827.x
Research Highlights
He J, et al. "Machine learning and integrative analysis identify the common pathogenesis of ." Frontiers in immunology, 2023.
Recent evidence suggests that COVID-19 may lead to azoospermia, however the underlying molecular mechanism remains unclear. This prompted a study aiming to investigate this complication further. Through the use of weighted co-expression network analysis, machine learning methods, and single-cell RNA sequencing, common differentially expressed genes (DEGs) and pathways were identified between azoospermia and COVID-19. Results showed that these diseases shared a common immune system and infectious virus diseases-related pathways, with several key hub genes (GLO1, GPR135, DYNLL2, and EPB41L3) identified. Further analysis also revealed a potential association between clinicopathological characteristics and azoospermia-related genes in COVID-19 patients. Additionally, the Xsum method was utilized to predict potential drugs, with single-cell sequencing data used to validate impaired spermatogenesis patterns in cryptozoospermia patients. This comprehensive bioinformatics analysis sheds light on the mechanisms and potential biomarkers of azoospermia and COVID-19, providing valuable insights for future research.
Pubmed:
37283758
DOI:
10.3389/fimmu.2023.1114870
Gutierrez-Ruiz JR, et al. "Expression profiles of GPR21, GPR39, GPR135, and GPR153 orphan receptors in ." Nucleosides, nucleotides & nucleic acids, 2022.
Orphan receptors remain an enigmatic class of receptors with unidentified endogenous ligands. They are expressed in diverse tissues and have been linked to various diseases including diabetes, hypertension, and cancer. The expression patterns of GPR21, GPR39, GPR135, and GPR153 orphan receptors were investigated in multiple tumor tissues. Real-time PCR analysis revealed elevated levels of GPR39 in cervical and prostate cancer tissues, while GPR21 and GPR135 were significantly downregulated in cervical, breast, skin, prostate, and astrocytoma tissues compared to healthy human fibroblasts. These findings suggest that GPR21 and GPR135 may play a role in cancer development while GPR39 may be involved in the progression of cervical and prostate cancer. These orphan receptors may serve as potential targets for new diagnostic and therapeutic approaches in oncology.
Pubmed:
35021931
DOI:
10.1080/15257770.2021.2002892
