mProX™ Human GPR12 Stable Cell Line

[CAT#: S01YF-0923-PY157]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

Certificate of Analysis Lookup
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Lot Number

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Product Information

Target Protein

GPR12

Target Family

Orphan Family

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1

Target Classification

GPCR Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Vulvar Dystrophy;Lennox-Gastaut Syndrome

Gene ID

Human: 2835

UniProt ID

Human: P47775

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

GPR12 is another orphan receptor that has been implicated in various cellular processes. Recent research has shown that GPR12 inhibits apoptosis in epithelial ovarian cancer through the activation of the ERK1/2 signaling pathway, suggesting its potential as a therapeutic target in cancer. Additionally, structural insights into GPR12 have revealed the determinants for its high basal activity, providing a foundation for future drug discovery efforts targeting this receptor.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Carol (Verified Customer)

What is the significance of GPR12 in cell proliferation? May 19 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR12, a G-protein-coupled receptor, has shown to play a role in cell proliferation. In a study, the GPR12-expressing hippocampal cell line HT22 reacted to sphingosylphophorylcholine with an increase in cell proliferation and cell clustering. May 19 2021

chat Donna (Verified Customer)

How can GPR12 be activated and what are its known effects? May 06 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR12 can be activated by its known ligand, sphingosylphosphorylcholine, which regulates cellular physiological activities including proliferation, neurite extension, cell clustering, and maintenance of meiotic arrest. May 06 2020

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