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  • mProX™ Human GIPR Stable Cell Line

    [CAT#: S01YF-0923-PY77]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Protein
    GIPR
    Target Family
    Glucagon Family
    Target Protein Species
    Mouse
    Host Cell Type
    3T3-L1;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Digestive and Renal Research
    Related Diseases
    Adrenal Cortical Adenoma;Adrenal Adenoma
    Gene ID
    Mouse: 381853
    UniProt ID
    Mouse: Q0P543

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GIPR is a receptor that plays a crucial role in glucose homeostasis. Recent studies have shown that GIPR agonism can inhibit PYY-induced nausea-like behavior, suggesting a novel mechanism by which GIP-based therapeutics may improve the tolerability of weight loss agents. Additionally, GIPR polymorphisms have been associated with therapeutic response to GLP1R agonists in Chinese patients with type 2 diabetes. Moreover, GIPR has been implicated in the regulation of differentiation, autophagy, and the release of inflammatory factors in pre-osteoblasts, providing insights into the molecular mechanisms of osteoporosis.

    Protocols

    Please visit our protocols page.

    Customer Reviews

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    FAQ

    chat Kathleen (Verified Customer)

    What role does GIPR play in the incretin system? Dec 03 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GIPR, the glucose-dependent insulinotropic polypeptide receptor, is a key component of the incretin system, mediating the insulin-releasing effects of GIP in response to nutrient ingestion. Dec 03 2022

    chat Dorothy (Verified Customer)

    How does GIPR influence postprandial glucose levels? Aug 30 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Activation of GIPR enhances insulin secretion in a glucose-dependent manner, helping to regulate postprandial glucose levels and maintain glucose homeostasis. Aug 30 2022
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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