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    mProX™ Human GALR1 Stable Cell Line

    [CAT#: S01YF-0923-PY71]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GALR1
    Target Family
    Galanin Family
    Target Protein Species
    Human
    Host Cell Type
    LX-2;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Chromosome 18Q Deletion Syndrome;Auditory Agnosia
    Gene ID
    Human: 2587
    UniProt ID
    Human: P47211

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GALR1 is a receptor for the neuropeptide galanin. Recent studies have highlighted its expression in colorectal cancer tissues and its potential correlation with overall survival and prognosis in colorectal cancer patients. Additionally, GALR1 has been associated with epigenetic alterations in colorectal carcinogenesis, suggesting its role in neoplastic progression. In the context of opioid withdrawal, GALR1's expression in the locus coeruleus has been studied, emphasizing its potential role in opioid responses.

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    FAQ

    chat Amy (Verified Customer)

    How does GALR1 immunoexpression correlate with the overall survival of colorectal cancer patients? Aug 29 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    High expression of GALR1 in the submucosal plexuses has been correlated with the overall survival of colorectal cancer patients, suggesting that GAL and GALRs might play a role in local neuro-paracrine pro-proliferative pathways accelerating the invasion and metastasis of cancer cells. Aug 29 2020

    chat Sharon (Verified Customer)

    Is there an epigenetic alteration in the GALR1 promoter during colorectal neoplastic progression? Nov 02 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, epigenetic alteration of the GALR1 promoter has been observed to accumulate gradually during colorectal neoplastic progression, indicating its potential as a promising biomarker for screening and surveillance of colorectal cancer. Nov 02 2021

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