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    mProX™ Human GABRA6 Stable Cell Line

    [CAT#: S01YF-1123-KX69]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    GABRA6
    Target Family
    GABAA
    Target Protein Species
    Human
    Host Cell Type
    NIH 3T3; CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Childhood Absence Epilepsy; Anxiety
    Gene ID
    2559
    UniProt ID
    Q16445

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The primary inhibitory neurotransmitter in the mammalian brain, gabapentin, functions through heteromeric pentameric ligand-gated ion channels, of which GABRA6 is a member of the GABA-A receptor gene family. Many significant pharmacologic drugs, such as ethanol, benzodiazepines, and barbiturates, operate through GABA-A receptors. One possible behavioral correlate of the GABA-A receptor subtype with alpha-6 subunit is cerebellar motor control. The benzodiazepine agonist diazepam can severely impair the postural reflexes of the selectively outbred alcohol-nontolerant (ANT) rat strain. Diazepam-insensitive high-affinity benzodiazepine binding is often absent from ANT cerebella, but in non-selected strains, this binding indicates a granule-cell-specific Alpha-6 subunit-containing GABA-A receptor. The customized GABRA6 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human GABRA6 Stable Cell Line (S01YF-1123-KX69). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat David (Verified Customer)

    What assays can the GABRA6 Stable Cell Line be used for? Apr 15 2022

    chat Sherry Smith (Creative Biolabs Scientific Support)

    This cell line is customized for drug discovery, and it also can be used in ELISA and Western Blots. Apr 15 2022

    chat Kathleen (Verified Customer)

    Can the GABRA6 stable cell line be used in drug discovery research? Jan 30 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Yes, the GABRA6 stable cell line can be used in drug discovery research and signaling pathway research. Jan 30 2020

    Related Products by Target
    • mProX™ Human GABRA6 Stable Cell Line (CAT#: S01YF-1123-KX69)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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