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    mProX™ Human GABRA5 Stable Cell Line

    [CAT#: S01YF-1123-KX68]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    GABRA5
    Target Family
    GABAA
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Developmental And Epileptic Encephalopathy; Non-Specific Early-Onset Epileptic Encephalopathy
    Gene ID
    2558
    UniProt ID
    P31644

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Alpha-aminobutyric acid The GABRA5 gene in humans codes for a protein known as a receptor, alpha 5, or GABRA5. In the mammalian brain, GABA is the primary inhibitory neurotransmitter that operates through ligand-gated chloride channels called GABAA receptors. Benzodiazepines are among the drugs that can alter the chloride conductance of these channels by binding to the GABAA receptor. It has been determined that GABAA receptors have at least 16 different subunits. Three distinct alternative non-coding first exons have been used to describe transcript variations. The customized GABRA5 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    FAQ

    chat Melissa (Verified Customer)

    How GABRA5 works? Apr 07 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    The ligand GABA is the endogenous compound that causes this receptor to open; once bound to GABA, the protein receptor changes conformation within the membrane, opening the pore in order to allow chloride anions (Cl−) and, to a lesser extent, bicarbonate ions (HCO3−) to pass down their electrochemical gradient. Apr 07 2020

    chat David (Verified Customer)

    How is GABRA5 associated with Alzheimer's Disease and other neurological disorders? Apr 10 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    A severe reduction of GABRA5 has been observed in a subset of patients with Alzheimer's Disease (AD) and Parkinson's Disease (PD). Apr 10 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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