mProX™ Human GABRA2 Stable Cell Line

[CAT#: S01YF-1123-KX65]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Ion Channel Cell Lines

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Lot Number

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Product Information

Target Protein

GABRA2

Target Family

GABAA

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

CNS Research; Pain and Addiction Research

Related Diseases

Developmental And Epileptic Encephalopathy; Alcohol Dependence

Gene ID

2555

UniProt ID

P47869

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The GABRA2 gene in humans codes for the protein known as gamma-aminobutyric acid receptor subunit alpha-2. The primary inhibitory neurotransmitter in the mammalian brain, GABA, activates GABA-A receptors, which are ligand-gated chloride channels that include the alpha subunit GABRA2. Benzodiazepines are among the drugs that can alter the chloride conductance of these channels by binding to the GABA-A receptor. Subunit isoforms can be observed throughout development in the brain at different places. The pharmacological and biophysical properties are greatly influenced by the subunit combinations. It has been discovered that GABRA2 mediates anxiolytic action, which is essential for controlling emotions and behavior. The majority of GABRA2 alterations have been connected to teenage behavior and alcoholism. The customized GABRA2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Kathleen

I was very pleased with the QCs of the cell line. Mar 22 2021

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chat Patricia

I had a wonderful encounter with this business. Excellent client service was provided. Sep 07 2022

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FAQ

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