mProX™ Human FPR1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Apoptosis in SiHa cells with FPR1 knockdown was studied using FACS.
In SiHa cells, a notable surge in the rate of apoptotic cell occurrence was observed when FPR1 expression was suppressed, as opposed to the control cells. These findings underscore the pivotal role of FPR1 downregulation in promoting apoptosis among SiHa cells.
Ref: Cao, Guangming, and Zhenyu Zhang. "FPR1 mediates the tumorigenicity of human cervical cancer cells." Cancer Management and Research (2018): 5855-5865.
Pubmed: 30510453
DOI: 10.2147/CMAR.S182795
Research Highlights
Ren T, et al. "Identification and validation of FPR1, FPR2, IL17RA and TLR7 as immunogenic cell ." Scientific reports, 2023.
The study explores the relationship between Immunogenic Cell Death (ICD) and the development of Osteoarthritis (OA) at the gene level through bioinformatics analysis. Limma R package was used to identify differentially expressed genes (DEG) and weighted gene co-expression network analysis to determine OA-related module genes. The DEGs and ICD-related genes were overlapped, and hub genes were identified using various analyses. The expression levels and diagnostic value of these hub genes were evaluated, along with their correlation to infiltrating immune cells and immune pathways. The expression of FPR1, FPR2, IL17RA, and TLR7 was verified in a rat knee joint model of OA and in IL-1beta induced rat chondrocytes. Four hub genes (FPR1, FPR2, IL17RA, and TLR7) were identified as potential biomarkers for OA associated with ICD. Knockdown of TLR7 reversed collagen II and ADAMTS-5 degradation in IL-1beta-stimulated chondrocytes, suggesting its potential as a therapeutic target for OA. This study provides new immune-related biomarkers for OA diagnosis and could guide future disease treatment.
Pubmed:
37803031
DOI:
10.1038/s41598-023-43440-z
Paterson NM, et al. "Dynamic evolution of bacterial ligand recognition by formyl peptide receptors.." Genome biology and evolution, 2023.
In the study, the detection and understanding of invasive pathogens was determined to be crucial for the host's immune defense. The recognition of these pathogens by cell surface receptors triggers a series of immune responses, including leukocyte recruitment, phagocytosis, release of antimicrobial compounds, and cytokine production. Researchers examined the evolutionary patterns and functional consequences of immune receptor divergence in the formyl peptide receptor (FPR) family of G-protein coupled receptors. They found that FPR1, a crucial receptor for innate immune defense in humans, has been lost in New World primates. The study also revealed repeated positive selection on extracellular domains in primate and carnivore FPRs involved in ligand recognition, indicating their role in evolutionary adaptation to diverse microbial ligands. The researchers further investigated the impact of FPR divergence on bacterial ligand interactions and discovered that a few highly variable amino acid sites in primate FPRs can significantly affect recognition of bacterial proteins, highlighting the role of natural selection in fine-tuning FPR activation in response to different pathogens.
Pubmed:
37776517
DOI:
10.1093/gbe/evad175
