mProX™ Human ESRRG Stable Cell Line

Product Information

Target Protein

ESRRG

Target Family

Estrogen-related Receptor

Target Protein Species

Human

Host Cell Type

ESCC; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Reproductive Research

Related Diseases

Usher Syndrome; Amelogenesis Imperfecta

Gene ID

2104

UniProt ID

P62508

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The ESRRG gene in humans encodes the nuclear receptor known as estrogen-related receptor gamma (ERR-gamma), or NR3B3. This protein belongs to the family of steroid hormone receptors known as nuclear hormone receptors. The orphan receptor lacks a physiological activating ligand; nonetheless, inverse agonists such as diethylstilbestrol and 4-hydroxytamoxifen deactivate ESRRG. Variations in bisphenol A effects could be explained by varying ERR-γ expression in different body areas. For example, observations of excessive bisphenol A accumulation in the placenta may be explained by the high quantity of ERR-γ detected there. The customized ESRRG stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Melissa

Its user-friendly design have simplified the process of ESRRG drug discovery in our lab. Jul 11 2022

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chat David

I have used the mouse ESRRG KD cell line extensively in my studies, and it consistently delivered outstanding performance. May 21 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 ESRRG inhibits the expression of key glycolytic enzyme PKM2 in ESCC cells.

Effects on PKM2 expression in ESCC cells of ESRRG overexpression and knockdown. Western blotting and immunohistochemistry to measure the PKM2 protein level in mouse xenograft tumors following overexpression or knockdown of ESRRG.

Ref: Wang, Tianxiao, et al. "ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy." Journal of Translational Medicine 21.1 (2023): 605.

Pubmed: 37679788

DOI: 10.1186/s12967-023-04347-5

Research Highlights

These results point to an unknown reliance of Rb cells on ESRRG and suggest that ESRRG may represent a therapeutic weakness in Rb.
Field, Matthew G., et al. "RB1 loss triggers dependence on ESRRG in retinoblastoma." Science advances 8.33 (2022): eabm8466.
Pubmed: 35984874 DOI: 10.1126/sciadv.abm8466

Sophoridine improves the anti-tumor impact of cisplatin and exerts tumor-suppressive effects in gastric cancer cells via targeting the ESRRG/β-catenin pathway.
Peng, Zhiyang, et al. "Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer." BMC cancer 20.1 (2020): 1-12.
Pubmed: 32571331 DOI: 10.1186/s12885-020-07067-x