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    mProX™ Human ERBB3 Stable Cell Line

    [CAT#: S01YF-1023-PY152]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HCT116
    Target Classification
    Kinase Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Lethal Congenital Contracture Syndrome 2; Visceral Neuropathy, Familial, 1, Autosomal Recessive
    Gene ID
    Human:2065
    UniProt ID
    Human:P21860

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    ERBB3, also known as human epidermal growth factor receptor 3, has various applications in different fields. In the context of adult hippocampal neurogenesis, ERBB3 binding protein 1 (Ebp1) acts as a modulator of neurogenic factors, contributing to the development of new neurons in the adult hippocampus. In liver cancer, miR-624, which targets ERBB3, accelerates the growth of cancer cells. In endometriosis, ERBB3 is involved in the interaction between macrophages and Schwann cells, potentially contributing to the pathogenesis of the disease. Additionally, in pancreatic cancer, cancer-associated fibroblasts (CAFs) can secrete NRG1, which activates ERBB2 and ERBB3 receptors in cancer cells, enabling bypass of oncogenic KRAS mutations. Finally, in ALK-positive non-small cell lung cancer, HER3 (ERBB3) may play a role in mediating resistance to ALK tyrosine kinase inhibitors, suggesting that targeting both ALK and HER3 could be a potential therapeutic strategy.

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    FAQ

    chat Peyton Jones (Verified Customer)

    How does ERBB3 contribute to drug resistance in lung cancer? May 18 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ERBB3 signaling can be activated by MET amplification, leading to drug resistance in lung cancer, particularly against gefitinib. May 18 2022

    chat Peyton Davis (Verified Customer)

    What is the role of ERBB3 in glioblastoma? Jan 24 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ERBB3 has been identified in the nucleolus of glioblastoma cells, suggesting a non-canonical pathway that these cells use for ribosome synthesis and proliferation. Jan 24 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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