mProX™ Human ERBB3 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Product Properties
Protocols
Please visit our protocols page.
Customer Reviews
There are currently no Customer reviews or questions for mProX™ Human ERBB3 Stable Cell Line (S01YF-1023-PY152). Click the button above to contact us or submit your feedback about this product.
Peyton Jones (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Peyton Davis (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 Suppression of ERBB3 gene expression led to a notable G1 cell cycle arrest within HCT116 cells.
The analysis of cell cycle distribution was conducted using FACS, 72 hours post-transfection with various concentrations of siRNA on the left, and at varying time intervals following treatment with 5 nM of siRNA on the right. The figures within the open box represent the percentage of G1 populations, revealing distinctive patterns in response to siRNA concentration and treatment duration.
Ref: Lee, Hyunji, et al. "ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells." Oncotarget 5.13 (2014): 5138.
Pubmed: 24970817
DOI: 10.18632/oncotarget.2094
Research Highlights
Kim, Youngkwan. et al. "ErbB3 binding protein 1 contributes to adult hippocampal neurogenesis by modulating Bmp4 and Ascl1 signaling." BMB reports, 2023.
In this study, researchers investigated the role of ErbB3 binding protein 1 (Ebp1), a molecule known for its involvement in embryonic neurodevelopment, in modulating adult hippocampal neurogenesis (AHN). Through experiments on Ebp1 neuron-depleted mice, they found that Ebp1 plays a crucial role in regulating adult neurogenic factors. Ebp1 was found to repress the transcription of Bmp4 and decrease the methylation of the Ascl1 promoter, leading to impaired AHN in these mice. These findings suggest that Ebp1 may act as an endogenous modulator of the interactions between Bmp4 and Ascl1/Notch signaling in the adult hippocampus, contributing to AHN. The researchers propose that further investigation into Ebp1 could shed light on the molecules involved in AHN.
Kim, Youngkwan. et al. "ErbB3 binding protein 1 contributes to adult hippocampal neurogenesis by modulating Bmp4 and Ascl1 signaling." BMB reports, 2023.
Pubmed:
37817439
DOI:
No
Jiang, Xiaoxue. et al. "miR-624 accelerates the growth of liver cancer cells by inhibiting EMC3." Non-coding RNA research, 2023.
In recent years, miRNA has emerged as a significant noncoding RNA, with over one-third of human genes being targeted by it. On human chromosome 14, miR-624 is present and has been linked to tumorigenesis. However, the role of miR-624 in human hepatocarcinogenesis remains uncertain. Research findings reveal that miR-624 promotes the growth of liver cancer cells. These results suggest that miR-624 may have a crucial role in the development and progression of hepatocellular carcinoma.
Jiang, Xiaoxue. et al. "miR-624 accelerates the growth of liver cancer cells by inhibiting EMC3." Non-coding RNA research, 2023.
Pubmed:
37810370
DOI:
10.1016/j.ncrna.2023.09.005
