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  • Human ERBB3 Membrane Protein Lentivirus

    [CAT#: S01YF-1124-KX46]
    Product Category:
    Membrane Protein Tools
    Subcategory:
    Membrane Protein Lentivirus

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
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    Lot Number

    Product Information

    Product Overview
    This product is a made-to-order lentivirus expressed human ERBB3.
    Target Protein
    ERBB3
    Target Classificationp
    Kinases/Enzyme
    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Protein Tag
    Based on specific requirements (Flag, StrepII, His, etc.)
    Buffer
    HBSS
    Titer
    ≧1.00E+8 TU/mL
    Transfer Plasmid Backbone
    pCDH or specific requirements
    Size
    100 uL*10 vials, 1 mL
    Fluorescent Markers
    EGFP, mCherry etc.
    Selection Markers
    Puromycin, Hygromycin, Neomycin, Blasticidin etc.
    Target Research Area
    CNS Research
    Related Diseases
    Lethal Congenital Contracture Syndrome; Visceral Neuropathy

    Quality Control

    Titer Determination Method
    RT-qPCR
    Sterility Testing
    Negative
    Mycoplasma Testing
    Negative
    Transfection Efficiency
    Positive (if EGFP is included in the transfer plasmid)
    Endotoxin Level
    Based on specific requirements

    Product Properties

    Application
    Stable cell line generation; Protein expression; Biochemical assays
    Safety Notes
    Since the HIV genes are expressed from packaging plasmids devoid of the packing signal, none of the HIV genes will be expressed in the transduced cells. The pseudotyped lentiviruses need to be used in a Biosafety Level 2 facility even if they are replication-incompetent.
    Shipping
    Dry ice
    Storage
    Store at -80°C and avoid repeated freeze-thaw cycles.

    Target

    Full Name
    Erb-b2 receptor tyrosine kinase 3
    Introduction
    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
    Alternative Names
    ERBB3; HER3; FERLK; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; human epidermal growth factor receptor 3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; Erb-b2 receptor tyrosine kinase 3
    Gene ID
    UniProt ID

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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