mProX™ Human EIF2AK2 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Morgan Garcia (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Cameron Brown (Verified Customer)
Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 The impact of EIF2AK2 downregulation on cell cycle progression and apoptosis in PANC-1 cells was investigated.
Cell apoptosis was assessed through flow cytometry in PANC-1 cells, with a noteworthy promotion of apoptosis observed upon sh-EIF2AK2 intervention (P<0.05 compared to Control and NC). EIF2AK2, identified as eukaryotic translation initiation factor 2α kinase 2, was targeted using small interfering RNA (siRNA) and short hairpin RNA (shRNA) techniques.
Ref: Du, Hao-Xuan, et al. "Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization." Oncology Letters 26.5 (2023): 1-21.
Pubmed: 37818134
DOI: 10.3892/ol.2023.14066
Research Highlights
Holubekova, Veronika. et al. "Differential gene expression of immunity and inflammation genes in colorectal cancer using targeted RNA sequencing." Frontiers in oncology, 2023.
In the study presented, the authors aimed to investigate the complex molecular mechanisms underlying colorectal cancer (CRC), a disease known for its heterogeneity and caused by various molecular changes such as driver mutations and gene methylations. They also explored the influence of the tumor microenvironment (TME), which contains immune cells with both pro- and anti-tumor functions, on the development and progression of CRC. By analyzing the expression patterns of inflammatory and immune-related genes, the authors identified aberrant signaling pathways involved in CRC carcinogenesis and metastatic potential, and their correlation with the Kirsten rat sarcoma virus (KRAS) gene mutation.
Holubekova, Veronika. et al. "Differential gene expression of immunity and inflammation genes in colorectal cancer using targeted RNA sequencing." Frontiers in oncology, 2023.
Pubmed:
37869102
DOI:
10.3389/fonc.2023.1206482
Du, Hao-Xuan. et al. "Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization." Oncology letters, 2023.
The study aims to investigate the potential of eukaryotic translation initiation factor 2α kinase 2 (EIF2AK2) as a diagnostic and prognostic marker for pancreatic cancer. The researchers conducted immunohistochemical staining on clinical samples and analyzed RNA sequencing data to identify differentially expressed genes (DEGs). Functional enrichment analysis was performed on EIF2AK2-associated DEGs, and the clinical relevance of EIF2AK2 was determined through survival and regression analyses. A predictive nomogram model was created, and the function of EIF2AK2 was assessed in PANC-1 cells. The results suggest that EIF2AK2 may serve as a diagnostic and prognostic biomarker for pancreatic cancer and could potentially be targeted for treatment.
Du, Hao-Xuan. et al. "Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization." Oncology letters, 2023.
Pubmed:
37818134
DOI:
10.3892/ol.2023.14066
