mProX™ Human EIF2AK2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

EIF2AK2, also known as PKR (protein kinase R), is a gene that has been implicated in various diseases, including colorectal cancer (CRC), pancreatic cancer, COVID-19, ischemic heart failure (IHF) comorbidity, and breast cancer related to systemic lupus erythematosus (SLE). In CRC, EIF2AK2 was identified as one of the significantly differentially expressed genes (DEGs) and was associated with aberrant signaling pathways involved in carcinogenesis, metastatic potential of tumors, and KRAS gene mutation. In pancreatic cancer, EIF2AK2 was investigated as a potential diagnostic and prognostic marker, with higher expression observed in pancreatic cancer tissues compared to adjacent tissues. In COVID-19 and IHF comorbidity, EIF2AK2 was identified as one of the hub genes associated with disease progression, and its dysregulation was linked to immune dysregulation and increased cancer risk. In breast cancer related to SLE, EIF2AK2 was identified as a prognostic gene and had good predictive ability for the prognosis of breast cancer. Overall, EIF2AK2 appears to play a role in various diseases and may have potential applications as a diagnostic, prognostic, and therapeutic target.AW300:AW315