mProX™ Human DDR2 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1101	Magic™ Human DDR2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

DDR2

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

MHCC-97H; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Auditory and Otology Research; Reproductive Research

Related Diseases

Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type and Warburg-Cinotti Syndrome. Among its related pathways are GPCR Pathway and ERK Signaling

Gene ID

4921

UniProt ID

Q16832

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The DDR2 gene in humans encodes a protein called discoidin domain-containing receptor 2, or CD167b. Receptor tyrosine kinase 2 (RTK) is the receptor that possesses the discoidin domain. In order for cells to communicate with their surroundings, RTKs are essential. These chemicals play a role in the control of metabolism, differentiation, and cell proliferation. Collagen binds to the extracellular discoidin domain of DDR2 in this instance. The pleiotropic effects of signal transduction are mediated by the phosphorylation of cytosolic targets and their interaction with other molecules, which is caused via autophosphorylation. DDR2 has been linked to several illnesses, including as cancer and fibrosis. The customized DDR2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Ashley

The DDR2 cell line is easy to use, and the provided protocols are clear and straightforward. Its competitive pricing compared to other similar products on the market makes it an attractive option for researchers on a budget. Oct 21 2020

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chat Gary

The DDR2 cell line is approximately lower than other brands of reagents and I got similar results. Sep 10 2021

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 The expression of DDR2 in cell lines and HCC tissues.

Using qRT-PCR, DDR2 mRNA expression was measured in five hepatoma cell lines (MHCC-97H, HepG2, Huh-7, Hep3B, and SMMC-7721) and the immortalized normal human liver cell line L-02.

Ref: Xie, Binhui, et al. "DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1." Journal of Experimental & Clinical Cancer Research 34.1 (2015): 1-13.

Pubmed: 26362312

DOI: 10.1186/s13046-015-0218-6

Research Highlights

DDR2 is positively linked and overexpressed in GC patients with adverse clinical characteristics. Through mTORC2 activation and AKT phosphorylation, DDR2 facilitates the EMT process, which in turn promotes tumor growth and invasion.
Wang, Yu-Gang, et al. "DDR2 induces gastric cancer cell activities via activating mTORC2 signaling and is associated with clinicopathological characteristics of gastric cancer." Digestive diseases and sciences 61 (2016): 2272-2283.
Pubmed: 27010547 DOI: 10.1007/s10620-016-4116-3

Targeted small molecule inhibitors are not effective in treating most nonsmall cell lung cancers (NSCLCs), despite ten years of progress in precision medicine techniques. Previous research has revealed that Discoidin Domain Receptor 2 (DDR2) kinase mutations may be useful therapeutic targets in non-small cell lung cancers.
Terai, Hideki, et al. "Characterization of DDR2 inhibitors for the treatment of DDR2 mutated nonsmall cell lung cancer." ACS chemical biology 10.12 (2015): 2687-2696.
Pubmed: 26390252 DOI: 10.1021/acschembio.5b00655