mProX™ Human CMKLR2 Stable Cell Line

Product Information

Target Protein

CMKLR2

Target Family

Chemoattractant Family

Target Protein Species

Human

Host Cell Type

AGS;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research

Related Diseases

Lung Occult Small Cell Carcinoma;Achromatopsia 7

Gene ID

Human: 2825

UniProt ID

Human: P46091

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CMKLR2, also known as Chemokine-like Receptor 2, is a protein that has been the subject of various scientific investigations. While the specific research articles related to CMKLR2 were limited in the provided search results, it's known that chemokine receptors play a crucial role in mediating cell signaling and migration, especially in the immune system. These receptors are often involved in inflammatory responses and have been linked to various diseases, including autoimmune disorders and cancers. In the context of scientific research, understanding the function and regulation of CMKLR2 can provide insights into its potential therapeutic applications. For instance, targeting such receptors can lead to the development of drugs that can modulate immune responses, potentially benefiting conditions like autoimmune diseases or even cancer. In summary, CMKLR2, as a chemokine receptor, holds significant promise in the realm of scientific research, with potential applications in understanding disease mechanisms and developing therapeutic interventions.

Protocols

Please visit our protocols page.

Customer Reviews

There are currently no Customer reviews or questions for mProX™ Human CMKLR2 Stable Cell Line (S01YF-0923-PY32). Click the button above to contact us or submit your feedback about this product.

FAQ

chat Amanda (Verified Customer)

Are there any specific cell lines developed for CMKLR2 research? Mar 07 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

While there are no specific cell lines mentioned for CMKLR2, various cell lines can be modified to express CMKLR2 for research purposes. Mar 07 2020

chat Ronald (Verified Customer)

How does CMKLR2 interact with other proteins or pathways? Nov 07 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

The interactions of CMKLR2 with other proteins or pathways are still under investigation. It's crucial to refer to the latest research for detailed insights. Nov 07 2020

Published Data

Fig. Knockdown of GPR1 (CMKLR2) on AGS cells.

On the left, the research depicts the immunocytochemical pinpointing of CMKLR1 and GPR1 receptors within AGS cells, alongside their specific downregulation through siRNA treatment (indicated by arrows, marking cells with positive staining). Meanwhile, on the right, the study quantifies the cells displaying positive CMKLR1 and GPR1 staining post-siRNA knockdown (represented by open bars for CMKLR1 and shaded bars for GPR1 staining proportions).

Ref: Kumar, J. Dinesh, et al. "Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: Putative role of decreased TIMP-1 and TIMP-2." Oncotarget 10.2 (2019): 98.

Pubmed: 30719206

DOI: 10.18632/oncotarget.26414