Recommended
Membrane Protein Drug Discovery In Vitro Assays Membrane Protein In Vitro Assay Kits Membrane Protein Stable Cell Lines Membranes Membrane Protein Virus Particles Membrane Staining and Imaging Reagents
  1. Home
  2. CMKLR1
  3. mProX™ Human CMKLR1 Stable Cell Line
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
    • 1- Membrane Protein Stable Cell Line-DiscoverMP Membrane Protein Stable Cell Line, Drug Discovery Tools
    1- Membrane Protein Stable Cell Line-DiscoverMP GPCR Cell Lines,Drug Discovery Tools
    Family stable cell lines Chemoattractant Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human CMKLR1 Stable Cell Line

    [CAT#: S01YF-0923-PY31]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Bulk Quote

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX279 Magic™ Rat CMKLR1 in Vitro Calcium Flux Assay Rat CHO-K1-Gα16 Calcium Flux Assay

    Product Information

    Target Protein
    CMKLR1
    Target Family
    Chemoattractant Family
    Target Protein Species
    Human
    Host Cell Type
    DU145;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Cardiovascular Research
    Related Diseases
    Monckeberg Arteriosclerosis;Cardiovascular Syphilis
    Gene ID
    Human: 1240
    UniProt ID
    Human: Q99788

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Chemokine-like receptor 1 (CMKLR1) has emerged as a pivotal player in various physiological and pathological processes. One of the promising areas of research is its potential application in demyelinating diseases, where novel CMKLR1 inhibitors are being explored. Another study has highlighted the upregulation of CMKLR1 in human bone marrow-derived mesenchymal stem cells compared to human embryonic fibroblasts, suggesting a potential role in stem cell recruitment and differentiation. Furthermore, the Chemerin/CMKLR1 axis has been implicated in the development of diabetic cardiomyopathy, where it promotes inflammation and pyroptosis. Silencing of the CMKLR1 gene might offer protection against this condition. Additionally, CMKLR1 has been identified as a functional receptor for amyloid-β peptide, suggesting its potential role in neurodegenerative diseases. In essence, CMKLR1's involvement in various cellular processes, from stem cell differentiation to inflammation, makes it a promising target for therapeutic interventions in a range of diseases.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CMKLR1 Stable Cell Line (S01YF-0923-PY31). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat David (Verified Customer)

    What are the potential therapeutic implications of CMKLR1 research? Dec 13 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Understanding CMKLR1's role in cellular pathways can lead to the development of targeted therapies and drug interventions. Dec 13 2020

    chat Deborah (Verified Customer)

    Are there specific challenges in researching CMKLR1 in stabilized cell lines? Aug 20 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    While challenges specific to CMKLR1 are not mentioned, cell line stabilization often requires addressing issues like genomic integrity and DNA damage repair. Aug 20 2022

    Related Products by Target
    • Magic™ Human FLAG tagged CMKLR1 HEK293T Cell Line, cAMP assay (CAT#: S01YF-1022-KX267)
    • Magic™ Human CMKLR1 CHO-K1/Gα15 Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX33)
    • Magic™ Human FLAG tagged CMKLR1 HEK293T Gαqi5 Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX268)
    • Magic™ Human CMKLR1 U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay (CAT#: S01YF-1222-KX42)
    • mProX™ Human CMKLR1 Stable Cell Line (CAT#: S01YF-0923-PY31)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare