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    mProX™ Human CLDN6 Stable Cell Line

    [CAT#: S01YF-1023-PY265]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;MDA-MB-231
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Hepatitis C Virus; Hepatitis C
    Gene ID
    Human:9074
    UniProt ID
    Human:P56747

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CLDN6, an oncofetal antigen, has potential applications in the treatment and diagnosis of various solid tumors, including colorectal cancer (CRC) and bladder cancer. In a phase 1 trial, CLDN6-specific CAR-T cells combined with an RNA vaccine showed manageable toxicity and promising results in relapsed or refractory solid tumors. The addition of the RNA vaccine was well tolerated, and the overall response rate was 33%. In CRC, CLDN6 was found to inhibit cancer proliferation by restraining p53 ubiquitination via the ZO-1/PTEN axis. Additionally, integrated bioinformatic analysis identified CLDN6 as one of the key claudin genes associated with survival prognosis and diagnosis in colon cancer. In bladder cancer, the dysregulation of purine metabolism genes, including CLDN6, was found to be associated with prognosis and could serve as a potential therapeutic target. These findings highlight the potential of CLDN6 in the development of targeted therapies and diagnostic tools for various solid tumors.

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    FAQ

    chat Skyler Garcia (Verified Customer)

    What is the significance of CLDN6 in solid tumors? Sep 17 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CLDN6, a tetra-membrane spanning protein, is aberrantly expressed in several cancers and may serve as an identifier for cells with cancer stem cell-like traits, making it an attractive target for tumor-specific therapeutic antibodies. Sep 17 2022

    chat Peyton Davis (Verified Customer)

    How does CLDN6 impact breast cancer cell behavior? Apr 03 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CLDN6 suppresses ERK signaling pathways in breast cancer cells, inhibiting their proliferation, migration, and invasion, suggesting its potential as a therapeutic target. Apr 03 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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