mProX™ Human CHRNA4/CHRNB2 Stable Cell Line
[CAT#: S01YF-1123-KX78]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
In roughly 12-15% of ADNFLE patients with a strong family history, the clinical phenotype is caused by the nAChR subunit genes CHRNA4 and CHRNB2. The brains of mammals express both genes, and the proteins they encode combine to form one of the most commonly expressed nAChRs (3α4/2β2 or 2α4/3β2). Given that mutations in these genes induce a seizure phenomenology that begins in the frontal lobe and seldom demonstrates subsequent generalization, the widespread expression pattern of this nAChR subtype is unexpected. The pathomechanisms preventing CHRNA4 and CHRNB2 mutations from having a more widespread effect are still just speculative. The customized CHRNA4/CHRNB2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Sandra
Its reliability and user-friendly design have simplified the process of CHRNA4/CHRNB2 drug discovery in our lab.
Sep 04 2021
Verified Customer
Karen
I have used the CHRNA4/CHRNB2 cell line extensively in my studies, and it consistently delivered outstanding performance.
Jan 12 2023
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
