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    Family stable cell lines Muscarinic Acetylcholine Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human CHRM3 Stable Cell Line

    [CAT#: S01YF-0923-PY129]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX639 Magic™ Rat CHRM3 in Vitro Calcium Flux Assay Rat CHO-K1 Calcium Flux Assay

    Product Information

    Target Protein
    CHRM3
    Target Family
    Muscarinic Acetylcholine Family
    Target Protein Species
    Human
    Host Cell Type
    PC3;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Metabolic Research
    Related Diseases
    Prune Belly Syndrome;Overactive Bladder Syndrome
    Gene ID
    Human: 1131
    UniProt ID
    Human: P20309

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CHRM3 is another member of the muscarinic acetylcholine receptor family, with its implications in various physiological and pathological processes. Recent studies have highlighted the role of CHRM3 in glioma, where its aberrant expression may contribute to tumor progression. Additionally, CHRM3 has been linked to cholinergic urticaria, where its reduced expression in sweat glands may contribute to impaired sweating responses. The receptor's involvement in sleep disturbances, particularly in the context of Alzheimer's disease, further underscores its significance in neurological research.

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    FAQ

    chat Barbara (Verified Customer)

    What role does CHRM3 play in glioma? Nov 20 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CHRM3-AS2, a long non-coding RNA associated with CHRM3, has been identified as a prognosis-associated differentially expressed RNA in glioblastoma (GBM). It is involved in mechanisms related to miR-370-5p/KLF4 in glioma. Nov 20 2022

    chat Dorothy (Verified Customer)

    How is CHRM3 linked to cholinergic urticaria and sweating? Aug 02 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Patients with cholinergic urticaria who have impaired sweating responses show reduced sweat gland epithelial expression of CHRM3. This reduction is associated with prolonged disease duration and increased disease severity. Aug 02 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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