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    mProX™ Human CHRM1 Stable Cell Line

    [CAT#: S01YF-0923-PY127]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX630 Magic™ Rat CHRM1 in Vitro Calcium Flux Assay Rat CHO-K1 Calcium Flux Assay

    Product Information

    Target Protein
    CHRM1
    Target Family
    Muscarinic Acetylcholine Family
    Target Protein Species
    Human
    Host Cell Type
    A375;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Anxiety;Trichothiodystrophy 7, Nonphotosensitive
    Gene ID
    Human: 1128
    UniProt ID
    Human: P11229

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The CHRM1 gene encodes the muscarinic acetylcholine receptor M1, which plays a crucial role in mediating various physiological responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels through the action of G proteins. In the realm of scientific research, CHRM1 has been implicated in various neurological and physiological processes. For instance, the receptor has been associated with cognitive functions, particularly in the context of Alzheimer's disease, where its dysregulation may contribute to cognitive decline. Additionally, CHRM1's role in modulating neurotransmission has made it a target of interest in the study of various neuropsychiatric disorders.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CHRM1 Stable Cell Line (S01YF-0923-PY127). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Kevin (Verified Customer)

    How is CHRM1 associated with Alzheimer's Disease and other neurological disorders? Oct 30 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    A severe reduction of CHRM1 has been observed in a subset of patients with Alzheimer's Disease (AD) and Parkinson's Disease (PD), potentially explaining the low efficacy of AChE inhibitors as a treatment for these patients. Oct 30 2020

    chat Paul (Verified Customer)

    What is the role of CHRM1 in melanoma suppression? Apr 15 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CHRM1 is inhibited by endogenous DOPA, which regulates melanocyte proliferative capacity and susceptibility to malignant transformation, indicating a potential role in melanoma suppression. Apr 15 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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