mProX™ Human CDK12 Stable Cell Line
[CAT#: S01YF-1123-KX178]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
CDK12
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
HCT116; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cardiovascular Research; Cancer Research; Reproductive Research
Related Diseases
Lung Cancer Susceptibility 3 and Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder. Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat.
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Cyclin Dependent Kinase 12 Protein is encoded by CDK12. Lung cancer susceptibility, congenital heart defects, dysmorphic facial features, and intellectual developmental disorder are diseases linked to CDK12. Gene expression (transcription) and the formation of the HIV elongation complex in the absence of HIV Tat are two of its associated mechanisms. Cyclin-dependent kinase that plays a crucial role in controlling transcription elongation by phosphorylating the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). controls the expression of genes necessary for DNA repair and is necessary to keep the genome stable. necessary for RNA splicing; phosphorylation of SRSF1/SF2 may be the mechanism. involved in controlling the activity of MAP kinase, which may impact how the body reacts to estrogen inhibitors. The customized CDK12 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Jason
The human CDK12 cell line was an indispensable tool in my research. The cell line's stability and reproducibility were outstanding, allowing for reliable results across multiple experiments.
Mar 18 2023
Verified Customer
Cynthia
The CDK12 cell line is of high quality and performs exceptionally well in my experiments.
Dec 29 2022
Verified Customer
FAQ
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