mProX™ Human CDK1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryBased on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.
Product Information
Product Properties
Protocols
Please visit our protocols page.
Customer Reviews
Rebecca
Verified Customer
Donna
Verified Customer
Any questions about our products? Please visit our frequently asked questions page.
Published Data
Fig.1 Protein levels of CDK1 and iASPP in CRC cell lines.
Western blot experiments were used to compare the protein levels of CDK1 and iASPP in five CRC cell lines-SW480, LoVo, HCT116, SW620, and HCT28-against the normal cell line, CRL-1831.
Ref: Gan, Wei, et al. "CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway." Oncotarget 8.42 (2017): 71618.
Pubmed: 29069733
DOI: 10.18632/oncotarget.17794
Research Highlights
The complete conclusion of M-phase in human cells necessitates the use of CDK1, the only critical cell cycle CDK. It is universally conserved in all eukaryotes and is the original member of the CDK family.
Brown, Nicholas R., et al. "CDK1 structures reveal conserved and unique features of the essential cell cycle CDK." Nature communications 6.1 (2015): 6769.
Pubmed:
25864384
DOI:
10.1038/ncomms7769
It is proposed that CDK1 would be the best CDK target for breast cancer therapy since selective blockade of CDK1 alone or in combination with other therapies has been linked to strong anti-cancer results.
Izadi, Sepideh, et al. "CDK1 in breast cancer: implications for theranostic potential." Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 20.7 (2020): 758-767.
Pubmed:
32013835
DOI:
10.2174/1871520620666200203125712
