mProX™ Human CD86 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- CD Cell Lines
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Published Data
Fig.1 Silencing of CD86 promotes in myeloma cell death
Lentivral particles containing either individual shRNAs or an empty vector (pLKO.1) were used to infect myeloma cell lines. The infection was observed for four days using annexin V-fluorescein isothiocyanate staining to measure cell death. The pLKO.1controls (left) were used to compare the data for each time point. Measurement of mRNA quantification using qRT-PCR, with levels of CD28 or CD86 compared to vector-controls (middle). On day four after infection, representative histograms display the surface levels of CD28 or CD86. Isotype controls are shown as thin gray histograms on the left (right).
Ref: Gavile, Catherine M., et al. "CD86 regulates myeloma cell survival." Blood advances 1.25 (2017): 2307-2319.
Pubmed: 29296880
DOI: 10.1182/bloodadvances.2017011601
Research Highlights
Liu, Zhenfeng. et al. "Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-[Formula: see text]B Signaling Pathway." The American journal of Chinese medicine, 2023.
Hemorrhagic shock is a common cause of mortality among trauma patients. The resulting inflammation may cause damage to the heart. A promising treatment for this condition is pachymic acid, a triterpenoid derived from Poria cocos. Studies have demonstrated its anti-inflammatory properties and potential for reducing cardiac damage.
Liu, Zhenfeng. et al. "Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-[Formula: see text]B Signaling Pathway." The American journal of Chinese medicine, 2023.
Pubmed:
37865871
DOI:
10.1142/S0192415X23500921
Zhao, Man. et al. "Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis." Medicine, 2023.
Carotid atherosclerosis (AS) is a common disease that affects the carotid artery and can lead to severe conditions such as transient ischemic attack and stroke. The relationship between pleckstrin (PLEK) and lymphocyte antigen 86 (LY86) and carotid AS is still not fully understood. To investigate this, the authors downloaded datasets GSE43292 and GSE125771 from the gene expression omnibus database and conducted differential gene expression analysis, weighted gene co-expression network analysis, protein-protein interaction network analysis, and functional enrichment analysis. They also identified 10 core genes (TYROBP, FCER1G, PLEK, LY86, IL10RA, ITGB2, LCP2, FCGR2B, CD86, CCR1) and found that PLEK and LY86 were highly expressed in carotid AS samples compared to normal samples. Furthermore, comparative toxicogenomics database analysis revealed 5 genes associated with pneumonia, inflammation, necrosis, and drug allergy. In conclusion, the study suggests that PLEK and LY86 play a significant role in carotid AS and may have prognostic value.
Zhao, Man. et al. "Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis." Medicine, 2023.
Pubmed:
37861500
DOI:
10.1097/MD.0000000000034445
