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    mProX™ Human CD38 Stable Cell Line

    [CAT#: S01YF-1023-PY175]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;H9C2
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Prolymphocytic Leukemia; Leukemia, Chronic Lymphocytic 2
    Gene ID
    Human:952
    UniProt ID
    Human:P28907

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CD38 is a protein that has various applications in different fields. In the context of autoimmune hemolytic anemia (AIHA), CD38 is targeted by monoclonal antibodies (MoAbs) such as daratumumab to effectively treat the disease. CD38 is also associated with disease progression in systemic sclerosis interstitial lung disease (SSc-ILD) and is expressed in plasma cells in SSc lungs. In the field of Parkinson's disease (PD), CD38 has been identified as a potential causal gene for the disease and may play a role in its pathogenesis. Additionally, genetic variability in the CD38 gene has been linked to individual differences in infants' cuddliness, indicating a role in the neurohormonal processes involved in pleasant touch. Finally, CD38 antibodies are used in cancer treatment, specifically in the context of injectable cancer drugs, although the association between CD38 and clinical benefit in terms of overall survival and tumor response is unclear.

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    FAQ

    chat Peyton Davis (Verified Customer)

    What is the role of CD38 in calcium signaling? Sep 29 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CD38 is a key enzyme in calcium signaling, with its activity influencing the levels of cyclic ADP-ribose (cADPR), a potent calcium-mobilizing agent. The membrane topology of CD38 defines its distinct functions in calcium signaling pathways. Sep 29 2023

    chat Alex Brown (Verified Customer)

    How does CD38 contribute to myocardial ischemia/reperfusion injury? Oct 22 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CD38 activation during myocardial ischemia/reperfusion leads to NAD(P)H depletion and impaired endothelial nitric oxide synthase function, contributing to reduced coronary flow and decreased contractile function in the heart. Oct 22 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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