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    mProX™ Human CD276 Stable Cell Line

    [CAT#: S01YF-1023-PY170]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;SCC1;SCC23;HN6
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Cancer Research;Immunology Research
    Related Diseases
    Immunodeficiency 16; Neuroblastoma
    Gene ID
    Human:80381
    UniProt ID
    Human:Q5ZPR3

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CD276, also known as B7-H3, is a potential therapeutic target and prognostic biomarker in various types of cancer, including central nervous system tumors, small-cell lung cancer (SCLC), hepatocellular carcinoma (HCC), and head and neck squamous cell carcinoma (HNSCC). In central nervous system tumors, CD276 is expressed in different subtypes, suggesting its potential as a target for antibody-drug conjugate (ADC) therapy. In SCLC, CD276 is overexpressed and is being investigated as a target for immune checkpoint inhibitors. In HCC, CD276 is associated with immune cell infiltration and may serve as a prognostic biomarker. In HNSCC, high expression of CD276 is correlated with poor prognosis, and targeting CD276 shows potential as a therapeutic strategy. Overall, CD276 has diverse applications in cancer research and therapy, making it an important molecule to study and target in various malignancies.

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    FAQ

    chat Taylor Miller (Verified Customer)

    What is the role of CD276 in cancer immunotherapy? Jul 13 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CD276, also known as B7-H3, is a potential therapeutic target in various cancers, including non-small cell lung cancer, due to its overexpression in tumor tissues and limited expression in normal tissues. Jul 13 2023

    chat Casey Jones (Verified Customer)

    How does CD276 expression influence tumor cell behavior? Apr 27 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CD276 expression in squamous cell carcinoma stem cells aids in immune escape, suggesting that targeting CD276 may reduce these cells in head and neck squamous cell carcinoma. Apr 27 2023

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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