mProX™ Human CD14 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CD14 is a protein that plays a role in various biological processes and has applications in different fields of research. In the context of synovial fluid in arthritis, CD14 dim , OPG + , ZO-1 + cells consistent with resident synovial macrophages (RSM) were identified. These RSM are migratory and can initiate or coordinate both acute (septic) or chronic (autoimmune or inflammatory) arthritis. In neuromyelitis optica spectrum disorder (NMOSD), excessive expression of MALAT1, an upstream target of miR-30b-5p, leads to upregulation of BAFF expression. This promotes the immunologic process of NMOSD by stimulating B cell activation and proliferation. CD14+ monocytes in peripheral blood mononuclear cells (PBMCs) mediate the anti-inflammatory effects of n-3 PUFA-rich lipid emulsions in parenteral nutrition. These lipid emulsions increase the expression of CD1d and CD86 in CD14+ monocytes, leading to increased IL-10 production and reduced pro-inflammatory cytokines. In long-COVID, CD14+ monocytes and NKT cells show altered expression and interaction, contributing to long-term pulmonary dysfunction and metabolic syndrome. In metabolic dysfunction-associated fatty liver disease (MAFLD), CD14+ monocytes differentiate into monocyte-derived macrophages (MdMs) that accumulate in the liver. These MdMs participate in lipid uptake during early stages of MAFLD. Overall, CD14 has implications in immunoregulation, autoimmune disorders, nutrition, pulmonary function, and liver disease.